1. < MAC & Bronchiectasis
Profile picture for scoop

Brinsupri follow-up

Posted by scoop @scoop, Sep 29, 2025

It seems a bunch of us have started Brinsupri. Let's use this thread for discussion. If you are taking Brinsupri have you noticed anything different, including changes to bronchiectasis or side effects? How long have you been on it?

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

Profile picture for melinda561
melinda561 | @melinda561 | Dec 20, 2025
In reply to @sharonednaramsey "@melinda561 I am colonized with pseudomonas. My BE specialist tells me that after 2 years it’s..." + (show)
Profile picture for sharonednaramsey @sharonednaramsey

@melinda561 I am colonized with pseudomonas. My BE specialist tells me that after 2 years it’s next to impossible to get rid of it. If I have flares or other symptoms he will treat it but right now I’m doing great with the combination of Brinsupri , nebs with albuterol and saline and airway clearance protocols. It’s hard to know what is making it better because it all pretty much started close together.

Jump to this post

@sharonednaramsey Thanks for your response.

REPLY
Profile picture for melinda561
melinda561 | @melinda561 | Dec 20, 2025
In reply to @mpowers501 "Sorry but I left that out. I am also colonized with pseudomonis. For that my ID..." + (show)
Profile picture for mpowers @mpowers501

Sorry but I left that out. I am also colonized with pseudomonis. For that my ID doc has an every other month routine. During the month I am medicating I nebulize 1ml of colistamethate every other day. And on the days I'm not nebulizing I take cipro 250 mg. And I do seem to be coughing up less lung crap at this time.

Jump to this post

@mpowers501 Thank you for follow up.

REPLY
Profile picture for scoop
scoop | @scoop | Dec 20, 2025
In reply to @wangling "@scoop, What recommended rinse do you use? Dr. Winthrop who was involved in the Brisupri trial..." + (show)
Profile picture for @ling @wangling

@scoop, What recommended rinse do you use? Dr. Winthrop who was involved in the Brisupri trial told me that during the trial people did not develop dental problems, only dogs did. But for us, it is good to take precautions.

Ling

Jump to this post

@wangling ACT or TheraBreath

REPLY
1 reply
Profile picture for cwal
cwal | @cwal | Dec 21, 2025
In reply to @robot "@melinda561 My question to ID would be - why hold off on Brinsupri?? Pseudomonas infection could..." + (show)
Profile picture for robot @robot

@melinda561 My question to ID would be - why hold off on Brinsupri?? Pseudomonas infection could still be treated normally - mine always is treated with Levaquin during flares. If I have another flare, I would still be treated with Levaquin. There is nothing precluding both treatments. The fact that Brinsupri inhibits Dpp1 enzyme from causing increased mucus buildup in lungs is a plus because its in essence diminishing a growing field for the pseudomonas.

Jump to this post

@robot
I agree! I believe that is why many of us who have Bronchiectasis with MAC (or our other various infections) and are taking Brinsupri report lessened symptoms and feel better. Your body's fight against the continuous inflammatory cycle of Bronchiectasis is lessened and is able to handle the "other" invader better.

REPLY
Profile picture for drewinsac
drewinsac | @drewinsac | Dec 21, 2025

Thanks, I just started brinsupri a few days ago, so no changes yet. I’ve been on azithromycin since October 2025 for PSA; it is gone now, and continue to use azithromycin and 2x inhalation amikacin daily. Not having an active infection (which was almost every two weeks after taking a month long of antibiotics) sure feels great.

REPLY
1 reply
Profile picture for blm1007blm1007
blm1007blm1007 | @blm1007blm1007 | Dec 21, 2025
In reply to @drewinsac "Thanks, I just started brinsupri a few days ago, so no changes yet. I’ve been on..." + (show)
Profile picture for drewinsac @drewinsac

Thanks, I just started brinsupri a few days ago, so no changes yet. I’ve been on azithromycin since October 2025 for PSA; it is gone now, and continue to use azithromycin and 2x inhalation amikacin daily. Not having an active infection (which was almost every two weeks after taking a month long of antibiotics) sure feels great.

Jump to this post

@drewinsac I am not sure what PSA is referring to especially since you cleared a problem with apparently only being on Azithromycin for a couple of months.????
If I interpreted it correctly...you were on/are on azithromycin and Brinsupri at the same time?
How nice "not having an active infection."
Barbara

REPLY
Profile picture for cholash
cholash | @cholash | Dec 22, 2025
In reply to @mariegrace "@mpowers501 I am happy to hear those on Brinsupri have less coughing. It may be a..." + (show)
Profile picture for mariegrace @mariegrace

@mpowers501

I am happy to hear those on Brinsupri have less coughing. It may be a placebo effect because, apparently results are not seen for a year.
All the best
Marie

Jump to this post

@mariegrace I’m 2+ months in on brinsupri , and I’m coughing significantly less , which is definitely attributed to less mucus . The mucus I do have has changed from always being very thick , to now it’s almost watery …thinner. I also have less. It’s been interesting..

REPLY
1 reply
Profile picture for heidi0974
heidi0974 | @heidi0974 | Dec 22, 2025
In reply to @cholash "@mariegrace I’m 2+ months in on brinsupri , and I’m coughing significantly less , which is..." + (show)
Profile picture for cholash @cholash

@mariegrace I’m 2+ months in on brinsupri , and I’m coughing significantly less , which is definitely attributed to less mucus . The mucus I do have has changed from always being very thick , to now it’s almost watery …thinner. I also have less. It’s been interesting..

Jump to this post

@cholash …May I ask if you’ve noticed more energy also? I’m just in my third week of Brinsupri. I’m very curious about any improvement with those who are ahead of me. Thank you! Jeanne

REPLY
1 reply
Profile picture for cholash
cholash | @cholash | Dec 22, 2025
In reply to @heidi0974 "@cholash …May I ask if you’ve noticed more energy also? I’m just in my third week..." + (show)
Profile picture for heidi0974 @heidi0974

@cholash …May I ask if you’ve noticed more energy also? I’m just in my third week of Brinsupri. I’m very curious about any improvement with those who are ahead of me. Thank you! Jeanne

Jump to this post

@heidi0974 No, I don’t think so. I have mild BE, and so far I’m not really tired from the disease unless I’m sick . Also, my 02 is generally good and doesn’t dip too much unless I’m sick . My biggest symptoms have been the thick mucus & constant coughing . Since Brinsupri , I’m producing less mucus, which helps me cough less. Also, the consistency of my mucus has changed - it’s rarely thick. I’m on 10mg. Good luck to you !!

REPLY
1 reply
View MoreView Less
Please sign in or register to post a reply.