@dragonflylynda I shake my 2 capsules into jar top, I take a sip of water before, throw caps into my mouth, and drink 8-10 oz of water......and take a few spoonfuls of yogurt......It's been 5+ years, no problem.......I think if you were a nurse/pharmacist handling these caps you might need gloves.....I take both at once, and don't let them sit on my tongue, down the hatch with lots of water.......scarier than it sounds......