Anyone with APS also have joint pain and severe fatigue?

Posted by cthomp77 @cthomp77, Dec 15, 2025

I was diagnosed with APS after a DVT and PE 26 years ago. In the last 5 years have been developing severe joint pain and fatigue. I have been tested for other autoimmune diseases and have come back mostly negative (ANA 1:80). I’m on plaquenil (not helping symptoms) but insurance is denying all other treatments because my blood tests remain inconclusive for lupus, sjogrens etc. I’m only 52. Frustrated in AZ

Interested in more discussions like this? Go to the Autoimmune Diseases Support Group.

Colleen Young, Connect Director | @colleenyoung | Dec 16, 2025

Welcome, @cthomp77. I moved your question to the Autoimmune Disease support group https://connect.mayoclinic.org/group/autoimmune-diseases/ where you will find many discussions about Antiphospholipid Syndrome (APS).

See all https://connect.mayoclinic.org/search/discussions/

Several members have talked about preventing blood clots like @scottham777 @bjbail70 @reets70 and others. @libbyh may also have experience with joint pain, fatigue and other autoimmune symptoms.

You might also find this discussion useful as you explore the possibility of additional conditions:
- Anyone else have multiple autoimmune diseases?https://connect.mayoclinic.org/discussion/anyone-else-have-multiple-autoimmune-diseases/