iSTOPMM study and the AI basics

Using technology I did an AI rundown of the iSTOPMM study (take it with a grain of salt)

Key Findings & Results:
MGUS & SMM Prevalence: Found MGUS in ~4.9% and SMM in ~0.5% of screened individuals (ages 40+). Prevalence increases with age and is higher in men.
Earlier Diagnosis: Screening identifies myeloma (MM) about a year earlier, with less severe features (fewer CRAB criteria).
Light Chain (LC) MGUS Definition: Developed new, age-adjusted reference ranges for serum free light chains (FLC), drastically reducing false positives and unnecessary worry by over 80%.
Psychological Impact: No increase in anxiety or depression in screened groups; structured support and information matter.
Risk Stratification Tools: Created a tool to help decide on bone marrow biopsies for SMM, reducing invasive procedures.
Infection Risk: SMM patients face an increased risk of infections compared to those with MGUS or no disease.
Hypercalcemia: Found primary hyperparathyroidism, not MM, is often the cause of hypercalcemia in MGUS.