I took Plaquenil for awhile and then had a severe reaction w/ hives. At the ER they thought I was going into Stevens-Johnson syndrome or Stevens Barr something. I'm not sure. I couldn't remember when I took Benadryl last so they hesitated to give me a shot or admit me. They finally gave me a shot-I've never had a shot that hurt that bad! By the next day it had calmed down but I had a pretty bad rash/hives for a month.

They got me into my RA doc the next day as an emergency appt and she said you don't look like you are going into SJS. I replied, "You should have seen me yesterday!" It was bad!