Skin cancer: Has anybody had fluorouracil treatment?

Posted by starship @starship, Dec 14, 2022

My parent has hit the point where she gets four or five pre-cancerouas growths on her face every year. The doctor has been freezing them off with good results.

The Dr. recently suggested she apply a fluorouracil lotion to her face two times a day for two weeks. Apparently, this kills off the defective skin cells and holds down the development of the pre-cancerous growths for about two years. But, my mom is worrying about the redness and unpleasnt effects of the treatment during the 2 to 3 weeks she is dealing with it.

Can anybody who has used this treatment pass on their experience. She wants to hear from people who have done the treatment.
Thanks.

Interested in more discussions like this? Go to the Melanoma & Skin Cancer Support Group.

Profile picture for cmorcat @cmorcat

@gingerw I do use only a small amount and rub it in good. I wasn't aware that it would be absorbed. My concern was it rubbing off and cross-contaminating things that others might come into contact with. Thank you for the info. Mark

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@cmorcat I will be interested to hear how your experience goes! When I first used it, areas I had not applied it to, reacted, and they didn't show as a problem spot [yet]. Oh, heavens, I thought I was having a bad reaction. Nope, just the medication finding the "bad guys".
Ginger

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Thank you for your help. I was wondering if it was ok to wear makeup in the beginning to hide some of the redness while at work.
Thank You
Julie

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I had a squamous carcinoma in situ on my nose and had it removed, but the margins were not completely cleared. The doctor decided to treat with fluorouracil for 6 weeks. There has been considerable redness and tenderness, and I am 5 weeks into the treatment. From readers experience with 6 week therapy, how long is it before the skin looks normal again?

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Profile picture for jultan @jultan

Thank you for your help. I was wondering if it was ok to wear makeup in the beginning to hide some of the redness while at work.
Thank You
Julie

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@jultan Personally, I would be careful about using makeup that might block the medication from absorbing into the affected areas. I am not a makeup expert, could you think about using a powder for a time, rather than a liquid as makeup?
Ginger

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Profile picture for dlw950 @dlw950

I had a squamous carcinoma in situ on my nose and had it removed, but the margins were not completely cleared. The doctor decided to treat with fluorouracil for 6 weeks. There has been considerable redness and tenderness, and I am 5 weeks into the treatment. From readers experience with 6 week therapy, how long is it before the skin looks normal again?

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@dlw950 Welcome to Mayo Clinic Connect! Dang, that's too bad the margins were not clear. Perhaps it is because of the location?

Everyone seems to have a similar experience when it comes to "getting back to normal" after using a fluorouracil treatment. In my experience, it was gradual after the treatments stopped, maybe a couple of weeks of lessening redness, then gone. At about the 4 week mark or so, I started using a light moisturizer on my face to help lessen the discomfort, making sure it was sparingly applied.

Have you returned to the doctor for post-procedure follow-up, yet? Have you posted this question to them, and what was their response?
Ginger

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Profile picture for Ginger, Volunteer Mentor @gingerw

@dlw950 Welcome to Mayo Clinic Connect! Dang, that's too bad the margins were not clear. Perhaps it is because of the location?

Everyone seems to have a similar experience when it comes to "getting back to normal" after using a fluorouracil treatment. In my experience, it was gradual after the treatments stopped, maybe a couple of weeks of lessening redness, then gone. At about the 4 week mark or so, I started using a light moisturizer on my face to help lessen the discomfort, making sure it was sparingly applied.

Have you returned to the doctor for post-procedure follow-up, yet? Have you posted this question to them, and what was their response?
Ginger

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The original excision was supposed to be followed by a Mohs surgery, but due to the prominent location, the doctor decided to do the fluorouracil treatment.
I have a follow up, but not for a couple of months. The treatment is on my nose, so I am hoping that I don’t look like
Rudolph the red nosed Reindeer for Christmas.

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