Hi there! I'm hoping I can help at least one person on this thread even if it is older. If you are struggling with high b6, have joint pain, muscle pain ect. Please also check your alkaline phosphatase. If that is low it is possible you have hypophosphatasia, a rare genetic metabolic bone disorder that presents in so many different ways. I was misdiagnosed for over 10 years with fibromyalgia and thank God my daughter's doctors took her seriously enough to get to the bottom of her pain, now there's 5 of us so far with the diagnoses.