Side effects of Pristiq

Posted by Native Floridian @nativefloridian, Jan 7, 2012

Has anyone successfully tapered off Pristiq? If so, what was your plan? I am considering going off this medicine. I take 50 mg per day and have done so for about 2 years. I understand there are very significant withdrawal symptoms and I would like to stop taking Pristiq because it causes my heart to race when the time release happens. I am afraid this medicine may not be good for the heart because the clinical trials state that anyone with a heart condition was not allowed to take it.

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I have been taking Pristiq for a month. I started with 25 mg and then it was raised to 50 mg. I have had no side effects so far which is very unusual for me. I have taken depression medications for years and suffered many side effects and withdrawal problems. I am encouraged with this medication, but now wonder what side effects to expect and when they begin. I have researched and tried to learn why I have so many problems with medications. I have three autoimmune illnesses and also have problems with those medications. I was diagnosed as an adult with autism spectrum disorder. and have a very rare blood type. Just wondering if this contributes to medications issues? Doctors are dismissive of my autism and continue to prescribe medications that have been problematic in the past. I was wondering what side effects people experience with Pristiq. Most of all, I would like to know if anyone has had success with this medication!

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Profile picture for 2112richard @2112richard

Now my question is how best can I come off off 20mg of fluoxetine daily? The transition from desvenlafaxine to fluoxetine was very easy.

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@2112richard, so glad to hear that the transition went well. Coming off that last low dose of fluoxetine should be done slowly and under the guidance of your prescribing doctor. This is one time where speed doesn't win the race.

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Profile picture for anonymouse @anonymouse

Hello! NOBODY should be weaning off this medication without advice from a doctor who knows what they are doing. Going cold turkey on this is DANGEROUS.
This tablet is extended release so It can't be cut and work quite the same. My doctor is kind and looks up stuff she doesn't know. So far my journey is going OK, but I'm still having withdrawal symptoms. I can't imagine going cold turkey bc the symptoms I have are awful.
I was on 50 mg, my doctor switched me to 25 mg for two weeks. Once I tolerated that change ( my side effects were nausea, light brain fog, not as bad as missing a pill. Now I'm on 25 mg every other day for two weeks. Everyday I don't take the pill I have brain fog, nausea, headache, I use the toilet a lot, am sleepy and irritable. Even though I'm a week, in the day I don't take a pill the symptoms are the same. If I can't tolerate this, there are options other than just doing every other day! My doctor said another option is to instead put me on Lexapro and start weaning using Lexapro, and you can cut Lexapro in half too. I may have to write her a message because I'm still trying to live my life and want less side effects while weaning off. It can be a long process!!
Please please do not try to do this yourself. See your doctor, do a telemed visit so you don't have to drive and see them. If your doctor doesn't seem to know that they are doing ask for a referral to someone who does because withdrawal is NOT easy even when doing a proper doctor overseen weaning method. Best of luck everyone!

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The extended release DOES work if you cut the pill as it is not related to the pill coating. Verified by the pharmaceutical manufacturer.
Hope this helps.

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Hi im in process of quitting Pristiq. 63 male 7 years on 100mg. Good drug if you want to be dumb and not worry about anything. Helped me from alcohol dependence. Now haven't had drink for 7 years yeee time to get my life back. So after reading all this lovely people story decided to quit Pristiq. One week 50mg second week 25mg now 3th day with 0mg. Got bad zaps yesterday but today is much better have filing im going to be good. Will post update. Ps. Sorry about my writing English is my second language

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Profile picture for mysza @mysza

Hi im in process of quitting Pristiq. 63 male 7 years on 100mg. Good drug if you want to be dumb and not worry about anything. Helped me from alcohol dependence. Now haven't had drink for 7 years yeee time to get my life back. So after reading all this lovely people story decided to quit Pristiq. One week 50mg second week 25mg now 3th day with 0mg. Got bad zaps yesterday but today is much better have filing im going to be good. Will post update. Ps. Sorry about my writing English is my second language

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Thank you some much for posting this! You're not alone feeling this way. At least now I know there are TWO of us. THREE of us?....

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Profile picture for mysza @mysza

Hi im in process of quitting Pristiq. 63 male 7 years on 100mg. Good drug if you want to be dumb and not worry about anything. Helped me from alcohol dependence. Now haven't had drink for 7 years yeee time to get my life back. So after reading all this lovely people story decided to quit Pristiq. One week 50mg second week 25mg now 3th day with 0mg. Got bad zaps yesterday but today is much better have filing im going to be good. Will post update. Ps. Sorry about my writing English is my second language

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Update.9 days without Pristiq Live is beautiful

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Profile picture for Savanti @savanti

Hi, you can get off of it, it will take some time, here is what I shared with a support group livng with mental illnesses and depression. You first need to change one thing with everything you do in a day. Meaning stop waking up to doing the same thing each morning, stop doing the same things as you go through the morning, stop doing the same things at lunch, the same for the rest of the day. What this means, you have been living one day to the next with about a 95% repeat of the things you did the day before. So, whats new in your life? What are habits? Habits are things you do without having to think about how to do them. Try to catching yourself doing two things at one time. This also means doing something and also thinking about something not relating to what you are doing. This is a bad habit. *You need to explore your five senses, eat something you have never tried, find new things to smell, listen to something different, engage in new ocnversations, walk away form the same old stuff, reach out to touch all surfaces, feel a flower, feel rough surfaces, feel running water on your hand, find new things to see. What this will do is stimulate your brain helping you to slowly come off your medication with little side effect.
Imagine having a sharp pain, the more you try to feel it, the stronger it will get. But, focusing on something new and different the pain isn't as bad. By doing new things, by taking risk to try something different while slowly over time reducing your intake of the medication will make it easier to get off of it. >I shared this with the group, four months later, a college girl told us she was able to reduce your med. intake by half and was feeling good enough to start dating again. by the time I left the group she was off her meds.
Change your daily habits. Explore your five senses. Find new things to do which means challenge yourself. Avoid interacting with wasteful conversations or activities which have no value. In the future, know that your brain can porduce any medication, all you need to do is change how you think. Thinking makes the brain produce good and bad chemicals

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Lovely thoughts but not helpful! Some of these medications are powerful and it can be really dangerous for some people to stop. You need a Dr's guidance on how to wean off Pristiq.

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I have been on 75/100mg Pristiq for a couple years after trying several different meds. I was diagnosed with a major depressive episode in 2019 and have been on meds ever since. I have been really struggling recently because I have realized I’ve lost the ability to feel joy. I simply don’t care about much of anything anymore. I am going to work with my dr to taper off Pristiq. I am in between jobs right now, so I feel like this is a good opportunity to get thru it without worrying about job performance. It is helpful to read others’ experiences — although it looks like this may be a lengthy process. If I wasn’t so numb, I would be hopeful.

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Profile picture for goldengirls328 @goldengirls328

Hope u get this message since u posted 2012. But your symptons are how i feel. Absolutely awlful. Even tappering with 12.5 is not any easier. How long before you felt normal?

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@goldengirls328 You posted in 2023. Were you able to get off of the Pristiq/Desvenlafaxine?

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Profile picture for kmunroe @kmunroe

I wanted to post this to help anyone withdrawing or considering withdrawl from pristiq.I was taking 50 mg's per day for 2 years. I didn't want to take any drugs anymore. I wanted to "battle" on my own. No judgement - I hated my side effects from the drug. I experienced a signifigant lack of intrests in all things creative, sex, music (i am a life long musician) Also I felt it deadened my ability to be passionate about anything? I never actually "felt" anything while taking the drug? Before I started it I felt absolutely hopeless, if not for my animals I don't know what I may have done. ok - I decided 6 weeks ago I was getting off this drug. I spoke with my doctor and started to taper. 50 mg everyother day for 10 days, than I cut the pills in half(yes I know NOW there was a time release coating) for 10 days, than cut into quarters (12.5 mg's for 5 days, now 3 days completely off. IT HAS BEEN VERY DIFFICULT. This drug is a beast. Side effects have included horrible VIVID nightmares of betrayl, weird taste in my mouth, weird smells, weight all over the map, feeling like constant out of body experience, mood swings, despair, insomnia. But - it is getting better every day. There is life after pristiq... I have focussed through all of my symptoms on knowing - it is the withdrawl! NOT ME! Hard to do. But do able. Just know in your core it is the drug NOT YOU losing it. For me - it seems like this drug surpressed my emotions/feelings/issues the moment it got in my system and now i'm dealing with these issues again as I coming off the drug. I admit I am way better suited Now compared to 2 years ago to deal with these things and not everybody will be as "LUCKY" as I am, so just know that. Also, I let everyone close to me know what I was doing for support reasons. If anyone has any questions I would humbly lend advice and support. MY DOCTOR IS COMPLETELY INEPT AND INCOMPETENT RE: PRISTIQ AND ALL MATTERS RELATING TO PRISTIQ! Remember - you are NOT alone. Just reach out...

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@kmunroe
Hi! I was on 50mg for 5 months then in the hospital the Dr upped it to 100mg. So I took 2 50mg a day for 3 months till my 50’s ran out. I was unable to get a refill for 2 weeks! My PCP was never informed of this. . So I cold turkey and it was HELL!! I got a new prescription for 100mg and went back on 3 days ago OMG! The paramedics just left my house. It’s Sunday so can’t get a hold of anyone. My vitals were fine even though I haven’t slept a wink in 3 days…sweats, chills, heart pounding out of my chest, dizzy and can’t put the lights on! My vitals were fine so I didn’t go to the hospital. I really don’t want to be on this anymore! I found a 50mg under my bed and think I’ll take that tonight instead of 100. I hope that doesn’t screw me up but I need to taper down. I just found out on here that you can’t split in half. Don’t mess with this medication.

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