I just joinned, and I am delighted to participate in this forum. I have been reading AD literature for the last couple of years due to family history of ADs. I am not a physician or medical professional but was trained as a chemical engineer. I am going to start taking a very low dose of lithium orotate once I receive the shipment. Earlier today, I went through the recent Nature paper by Aron Liviu etal from Harvard and decided to explore this subject by some self-experimentation in a scientific way.
As we all know, safety is a paramont concern when taking any supplements so I searched low dose lithium long term toxicity in the medical literature but found little. There are well established renal toxicity when prescribed at very large dosage of 300 to 400mg of lithium carbonate which has very low bioavailibility. On the other hand, lithium orotate has very high bioavailibility due to the orotate ions help lithium ions get into cells, especially in the brain. Thus, how much lithium ions in the blood and how long they stay becomes important.
I searched the lithium orotate half life in blood (hours of 50% of lithium ion still remaining in blood after introduction) and found 24 to 36 hours, however, long term use increases half life to 48 to 64 hours. Thus, I think it will be a good idea to take lithium orotate every other day or every third days in stead of every day.
I sincerely welcome any discussions on this subject.
@oldelectrician i am taking 5mg daily x 7 weeks now. No side effects whatsoever. In the mouse studies it took 9-12 mos for amyloid plaque to resorb. No idea how long it will take in humans since inexplicably there are no trials underway.
@oldelectrician i am taking 5mg daily x 7 weeks now. No side effects whatsoever. In the mouse studies it took 9-12 mos for amyloid plaque to resorb. No idea how long it will take in humans since inexplicably there are no trials underway.
@pb50 great to not have side effects, but how does one calibrate dosage and timing of dosage ? …Must be someone who’s got some useful info from rom other humans taking this…
There is a lot of data - start with a Harvard Study reported in Nature Magazine. For what it’s worth the reporting is focused on what is termed Low Dose Lithium in a salt
Carrier of sorts called Orotate. The Low Dose used is most commonly 5mg.
NIH-supported research indicates that the lithium component of lithium orotate may support cognitive function and offer neuroprotective effects, particularly at low doses. While lithium orotate has been studied for its potential cognitive benefits, it is not an FDA-approved drug and is sold as a dietary supplement.
There is a lot of data - start with a Harvard Study reported in Nature Magazine. For what it’s worth the reporting is focused on what is termed Low Dose Lithium in a salt
Carrier of sorts called Orotate. The Low Dose used is most commonly 5mg.
NIH-supported research indicates that the lithium component of lithium orotate may support cognitive function and offer neuroprotective effects, particularly at low doses. While lithium orotate has been studied for its potential cognitive benefits, it is not an FDA-approved drug and is sold as a dietary supplement.
Thank you so much for your post. The references in that study have a lot of value to support that Li is an important trace element for many mental conditions, particularly AD. It's too bad there haven't been more definitive studies done. All Big Pharma wants to do is develop expensive new drugs with difficult names renamed for marketing purposes. Leqembi for example removes the plaque caused by the disease but doesn't treat the cause. The result is a short term delay in its progress with potentially dangerous side effects for some.
Thank you so much for your post. The references in that study have a lot of value to support that Li is an important trace element for many mental conditions, particularly AD. It's too bad there haven't been more definitive studies done. All Big Pharma wants to do is develop expensive new drugs with difficult names renamed for marketing purposes. Leqembi for example removes the plaque caused by the disease but doesn't treat the cause. The result is a short term delay in its progress with potentially dangerous side effects for some.
@longboat1 agree. The potential revenue generation from an inexpensive, readily available mineral health supplement that, at least in mice genetically altered to develop AD, , eliminates amyloid plaque in a year. So there is no money in “Look what we proved”!
When i informed my neurologist and my primary care Doc of my decision to proceed AMA, i gave that same response when they said “we” should wait for human trials. I explained that I understand it is mot approved foppr the purpose of mitigating AD and I may not achieve more than some mood lift. I could live with that. But the likelihood of major human trial conducted by a pharmaceutical company is not terribly likely in my personal opinion. Ditto for University research. They need patents more than ever. So I am proceeding with a mineral supplement that has minimal to- no downside and lots of potential upside in my view.
6 weeks ago I started with pure brand 1mg capsules to test for reaction and went up 1 mg per week until I got to 5 mg and switched to 5mg. capsules. No side effects good or bad. But we need to remember that 5mg is virtually nothing compared to the 600-1200mg given for bipolar disease.
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@hdeff I should have mentioned that. Thank you for clarifying that in my omission
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3 Reactions@oldelectrician i am taking 5mg daily x 7 weeks now. No side effects whatsoever. In the mouse studies it took 9-12 mos for amyloid plaque to resorb. No idea how long it will take in humans since inexplicably there are no trials underway.
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5 Reactions@pb50 great to not have side effects, but how does one calibrate dosage and timing of dosage ? …Must be someone who’s got some useful info from rom other humans taking this…
There is a lot of data - start with a Harvard Study reported in Nature Magazine. For what it’s worth the reporting is focused on what is termed Low Dose Lithium in a salt
Carrier of sorts called Orotate. The Low Dose used is most commonly 5mg.
NIH-supported research indicates that the lithium component of lithium orotate may support cognitive function and offer neuroprotective effects, particularly at low doses. While lithium orotate has been studied for its potential cognitive benefits, it is not an FDA-approved drug and is sold as a dietary supplement.
Just start reading .. search for Denmark Study and this article to start
https://www.psychiatryredefined.org/lithium-alzheimer-disease-and-a-turning-point-in-mental-health-care/
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3 ReactionsThank you so much for your post. The references in that study have a lot of value to support that Li is an important trace element for many mental conditions, particularly AD. It's too bad there haven't been more definitive studies done. All Big Pharma wants to do is develop expensive new drugs with difficult names renamed for marketing purposes. Leqembi for example removes the plaque caused by the disease but doesn't treat the cause. The result is a short term delay in its progress with potentially dangerous side effects for some.
-
Like -
Helpful -
Hug
3 Reactions@longboat1 agree. The potential revenue generation from an inexpensive, readily available mineral health supplement that, at least in mice genetically altered to develop AD, , eliminates amyloid plaque in a year. So there is no money in “Look what we proved”!
When i informed my neurologist and my primary care Doc of my decision to proceed AMA, i gave that same response when they said “we” should wait for human trials. I explained that I understand it is mot approved foppr the purpose of mitigating AD and I may not achieve more than some mood lift. I could live with that. But the likelihood of major human trial conducted by a pharmaceutical company is not terribly likely in my personal opinion. Ditto for University research. They need patents more than ever. So I am proceeding with a mineral supplement that has minimal to- no downside and lots of potential upside in my view.
6 weeks ago I started with pure brand 1mg capsules to test for reaction and went up 1 mg per week until I got to 5 mg and switched to 5mg. capsules. No side effects good or bad. But we need to remember that 5mg is virtually nothing compared to the 600-1200mg given for bipolar disease.
-
Like -
Helpful -
Hug
3 Reactions