Hi, I am Ellen. I have had RA for 15 years. Until I started biologics, it was crippling. The biologics are life changing. Unfortunately, there are problems with biologics. Initially, it can take several months for them to become fully effective. If you can hang on long enough though you can suddenly get your freedom of movement without pain back. How long will that take varies with each person. Sometimes they never work. You just have to suffer it out until you are sure it isn't going to work for you. If you are lucky though, within a few months, give or take a month, it will kick in! Then you have hit the jackpot! You get your life back. It is as if you were never crippled. It is intoxicating, in a good way. At least it is for me. What You have to remember is it is imperative that you get your infusions on time every time. The biologics take time to start working. Some I have been on started working in 30 days. Some, like the one I am on now, Simponi Aria, took 4 months. I almost gave up. Biologics also last as long as they last. There is no guarantee how long they will be effective. Every one's experience is different. Our bodies, over time, adjust to the biologics rendering them ineffective. Then we start over looking for the next one. It is just a fact of life for RA sufferers. Be thankful science has discovered these medicines that can give us months of relief at a time!