What do people do for chronic neuropathic pain?

@jeler
I have Hokas M Gaviota 5’s. A home health nurse recommended them. When I tried them on I had to hold onto the shoe racks and chairs to maintain my balance, but I had read a few reviews where several people had to wear them for months to break them in so I bought them and it took me a while to break them in as well, but not three months.
New Balance 990s are my favorite shoes. I also like New Balance 1540s, Mephistos which were the most comfortable when I had plantar fasciitis with the neuropathy. I also have SAS (San Antonio shoes.)
I usually switch shoes every couple of days. But sometimes I wear the 990s a week or two at a time.
The nurse said I would feel more stable in the hokas but I don't, however, I still wear them. I wonder if I had worn the Hokas longer if I would've felt more stable in them or maybe I bought the wrong Hokas. My neuropathy is at stage four so I don't have the horrible pain like I used to, only numbness.
Some people here recommend the barefoot/minimalist shoes, and I've read that many people like them. However, my doctors have advised against my wearing them.
Best of luck,
Jake

I am struggling with feet neuropathy for years and Tylenol and Naproxen are not working very well for numbness and pain. My neurologist recommended me Lyrica. Could you please tell me if it helped you and if it gave you sides effects? Thank you

I was recently diagnosed with sensorimotor poloyneuropahty and have been prescribed a low dose of Lyrica (pregabalin) 50 mg 3 x daily. I started this 9/26/25 and it has just begun kicking in. There is some relief. I'm thinking the neurologist will increase the dosage when returning for follow up visit in November. My blood test indicated a high level of B6, double the normal range, which could be the cause of the nephropathy. I don't take anything with b6 vitamins. It's very curious to me.
I wish you luck.
Joyce

@hotrod83 did your B6 toxicity ever clear up and I’m wondering if you took a multivitamin. After 10 months of agonizing pain finally diagnosed with B6 overload all from a simple multivitamin. I’m in a wheelchair because of it and can only walk about 10 feet. This has been the most miserable year of my life so my heart goes out to you. Thanks for your post.

@mrmacabre .try looking up what vitamin B12 does besides making blood cells. Then look up why alcohol stops B12 absorption.
Worked for my trigeminal neuralgia.
Off alcohol permanently now.
Good luck.

@jamessaxo
Hey brother I got the whole shabang and I'm still drinking! I'm just killing myself right now! I've been drinking for 5 years straight every day. I take the Gabapentin 300 and the lipic acid thing. I'm even injecting NAD+ , but it is not going away until I stop drinking. The symptoms started in January one night and haven't stopped. Thank you for listening if you get this!

LDN. I have severe axonal sensory motor Polyneuropathy with major muscle wasting in my lower legs. I need a motorized chair when I leave the house.

I have numbness and vibrating parathesias in my legs and sometimes hands. And also occasional nerve zaps. But no pain.

I’ve been on Low Dose Naltrexone (3mg) for 11 years. All my neurologists have tried to give me Gabapentin but I don’t need it.

Here’s an article explaining how LDN is effective for neuropathic pain. It may not help everyone but I will never go off it.
https://neuropathyresource.com/low-dose-naltrexone-neuropathy/

@db72 Hi there - I have had sensory idiopathic neuropathy with pins and needles and burning but 90% better because I take alpha lipoic acid 600 mg once a day and the brand name is Source Naturals - got it at the healthfood store here. It takes a week or two but my dr did not tell me about it - all he wanted to give me was Lyrica or gabapentin which were horrible - the fatigue even on the lowest dose was awful. I think it wouldn't hurt to try it - just a supplement and wont hurt you - the owner of the healthfood store takes it too. Hope you feel better soon.