Endometerial cancer with essential throbocythemia (ET) Jak 2 mutation

Posted by 1995victoria @1995victoria, 4 days ago

I recently came across a research study that indicated a connection between essential throbocythemia (ET) with Jak2 mutation and endometerial cancer (EC), and wonder if there are any women out there with this. I have both, the EC recently diagnosed.

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

Colleen Young, Connect Director | @colleenyoung | 1 day ago

@1995victoria, I added your question to both the Blood Cancer & Disorders support group as well as the Gynecologic Cancers support group. I believe this may be the research you're referring to:
- JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α https://pmc.ncbi.nlm.nih.gov/articles/PMC11669642/

Is your endometrial cancer diagnosis recent? What treatment have you had or will be having?

1995victoria | @1995victoria | 1 day ago

I'm thinking if I knew there was this Jak2 and endo cancer connection, I would have been monitoring my endometrial lining during the 5 years I've had ET Jak2. Maybe could have caught cancer earlier in its invasion. I wonder what else Jak2 mutation can be involved in. I thought it was only ET.

1995victoria | @1995victoria | 1 day ago

In reply to @colleenyoung "@1995victoria, I added your question to both the Blood Cancer & Disorders support group as well..." + (show)

@colleenyoung Diagnosed last Wednesday, meeting with Doctor next Wed to discuss next steps.

Colleen Young, Connect Director | @colleenyoung | 21 hours ago

In reply to @1995victoria "@colleenyoung Diagnosed last Wednesday, meeting with Doctor next Wed to discuss next steps." + (show)

@1995victoria, those are all good questions to ask at your next appointment with oncology. I would also ask if the JAK2 mutation influences which treatment options are best for you.