How long before anyone has seen improvement in their MAC journey?

A few months.

@sharondig not sure what you mean by "little change" but under the 2020 treating guidelines, if your sputum hasn't converted by 6 months, you need to change up your treatment regimen. For many that may mean adding Arikayce, switching to daily Big 3 if on Big 3 only 3x a week. It is going to depend on your individual circumstances, but the thinking is that if you have not sputum converted by month 6 on your current regimen you are not likely to. As for CT changes, not everyone sees improvement on CT, it may depend on your presentation, and cavity disease is its own separate discussion. Have you discussed with your doctor the lack of change? Do they have a plan for addressing? Are you seeing an NTM specialist? I think an NTM specialist is instrumental, particularly where initial treatment is not getting results.