@harper2018, welcome to Connect. You may notice that I moved your discussion and combined it with a discussion titled Prolia treatment for osteoporosis. I did this so your message would go to all of the members on Connect already discussion Prolia treatments. Here you will meet members like @tessie, @crenhov, @sashasl, @cairnmama, and @dolan, who have all disscused taking Prolia and may be able to share some insight on whether or not they experienced any constipation or any other side-effects.

I’ve received no replies should I repost

@harper2018, are you replying strictly by email? If so, I suggest clicking on VIEW & REPLY so you will be brought to the website. @cairnmama did reply that they continue to receive Prolia treatments and have not experienced side-effects. @harper2018, if you are comfortable sharing, has your constipation improved?

I do not see anything thatshows a view and reply only reply. So what do you mean. I am doing through email

The bottom of each email notification should contain a blue box that has VIEW & REPLY in it. This is important because sometimes email notifications are not always the full post due to length, and by clicking VIEW & REPLY and going to the full discussion, it is easier to know where you are in the conversation and who you are replying to. I have attached a photo that shows the box I am talking about in the email notifications. (I had to repost this message as I attached the wrong photo)

I am 64 on prolia for almost one year. Have a terrible gut before the Prolia: celiac disease, IBS-c, acid reflux. My constipation and loss of appetite problem has become severe in the last two months. Now dependent on laxatives which are creating new g.i. problems. I do have a suspicion that the Prolia is a contributing factor. In the process of getting to the bottom of this. Next injection supposed to be in May. Are you still on Prolia?

Yes, you are not alone. I have had this side effect.

To harper

@ harper2018 I have had IBS-C forever. I have now had 3 prolia injections and am due for the 4th in November. My tolerable and manageable constipation problem has become severe . As in your case, the endocrinologist seemed dismissive of this side effect. (I have read that constipation is a common side effect and is a reason why some people stop taking it.) Anyway, I continue to soldier on. I have stopped using Miralax, Milk of Magnesia and now use Sennokot on a fairly regular basis. I just recently found a product over the counter in the drugstore called " The right fibre 4 IBS Intestinal Discomfort Low Fodmap". It is made by Webber Naturals. (webbernaturals.com out of WN Pharmaceuticals in Coquitlam, B.C. 1-800-430-7898.) Like Miralax it dissolves in hot or cold beverages and has absolutely no detectable taste or grittiness . I have found that daily use of this has somewhat reduced my usage of sennokot and reduced some of the senna side effects. The fibre comes from guar gum and is a prebiotic. Instead of every two days every four or five days. I still suffer from quite a bit of bloating. Since the prolia, gastrointestinal I have never felt right. However, my bone density has improved significantly. I return to the gastroenterologist on Oct.7th but based on past experiences am not sure what can be done. He prescribed Linzess known as Constella in Canada and I had horrible pain from this med-- impossible to live with pain from that drug (at two different doseages). Sennokot with mild cramping is preferable (for me). I am just reading your message today eventhough you posted a year ago. So, it does seem that constipation is a side effect for some.

Did you continue with the Prolia injections? And if so, did you replace Prolia with something else? I have been dealing with this same issue (constipation, bloating, lower abdominal pain) which has worsened over time. My bone density has improved significantly . Due for the 4th injection in November.
I also seem to have even more back pain since being on Prolia.
Miralax stopped working for me. Now using sennokot.