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TKI vs Hydroxyurea

Posted by mjbulte @mjbulte, Jul 27 8:18am

What happens when you switch from Hydroxyurea to a TKI medication? Looking to likely switch and want to know what to expect. Am tolerating Hydroxyurea very well, so anxious about switching.

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mjbulte | @mjbulte | 1 day ago
In reply to @loribmt "Hi @mjbulte. I don’t have any personal experience with Danziten but a little sleuthing this morning..." + (show)
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Hi @mjbulte. I don’t have any personal experience with Danziten but a little sleuthing this morning shows it’s a revised version of Nilotinib (Tasinga) which you mentioned.

Here’s the briefing from Azurity Pharmaceuticals:
https://azurity.com/azurity-pharmaceuticals-inc-announces-fda-approval-of-danziten-nilotinib-tablets-the-first-and-only-nilotinib-with-no-mealtime-restrictions/
I haven’t found any members specifically mentioning Danziten yet. But since it’s a relatively new drug on the market it may take a little time for more replies to trickle in.
Fingers crossed for the drug approval! In the meantime, are you still taking the HU?

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@loribmt
I started Danziten (half dose) last week. So far no severe side effects, just a bit more fatigue than normal and inflammation if I eat sugar. Blood work to be done soon and that should show how well, or not, this medication is working. So far, I haven’t heard from anyone who is taking Danziten. I’m feeling like a guinea pig!

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Lori, Volunteer Mentor | @loribmt | 1 day ago
In reply to @mjbulte "@loribmt I started Danziten (half dose) last week. So far no severe side effects, just a..." + (show)
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@loribmt
I started Danziten (half dose) last week. So far no severe side effects, just a bit more fatigue than normal and inflammation if I eat sugar. Blood work to be done soon and that should show how well, or not, this medication is working. So far, I haven’t heard from anyone who is taking Danziten. I’m feeling like a guinea pig!

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@mjbulte I was looking for an emoji of a guinea pig. 🐹☺️
Even though the Danziten you’re taking is relatively new there’s the reassurance that its foundation is an effective drug that was approved by the FDA in 2007 (nilotinib/Tasigna). Just modified so that you don’t have to fast before taking.
Reading the info on both drugs I can see why there would a push to redesign it. Having to fast 2 hours before and 1 hour after taking Tasinga (every 12 hours) would get pretty old leaving it a challenging schedule to adhere to.

Your comment about sugar and inflammation is really interesting. I’ve found the same thing too. I tend to stay away from any excess sugars and starchy foods. But if I have a moment of indiscretion…oops! 😅 I seem to pay for that with not feeling my usual perky self the next day. Our diets really do make a difference. Ho hum…but sometimes I just need to indulge in dark chocolate…

Will you let me know how your labs turn out?

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