@mrsjohn101 Oh yes. I am fully aware that any anti-biotic, even a topical one, could cause C Diff to return. Some doctors told me it’s the broad-spectrum antibiotics that are the most concerning, but other docs have told me that ANY antibiotic could be problematic. I am working hard to build my microbiome back to be as healthy and diverse as possible so that hopefully, if I ever have to take antibiotics again, my gut will be healthy enough to survive without a recurrence.