Lithium Orotate Usage and Alzheimer’s

What dosage are you going to be taking? I can't find anything to use as a guide. I bought 5mg pills, but decided to split them into quarters. It's all a guessing game right now.

So far I have not found any lithium orotate in pill form, they are capsoles and difficult to split. The FDA office of dietary supplement suggest a daily intake of 0.3 to 3mg, thus I am taking a 5mg capsole every third days. Please let me know where you buy the pill form. Thanks

I got mine on eBay. The brand is Lindens and they came from the UK. Lindens seems like a reputable company.

I just joinned, and I am delighted to participate in this forum. I have been reading AD literature for the last couple of years due to family history of ADs. I am not a physician or medical professional but was trained as a chemical engineer. I am going to start taking a very low dose of lithium orotate once I receive the shipment. Earlier today, I went through the recent Nature paper by Aron Liviu etal from Harvard and decided to explore this subject by some self-experimentation in a scientific way.
As we all know, safety is a paramont concern when taking any supplements so I searched low dose lithium long term toxicity in the medical literature but found little. There are well established renal toxicity when prescribed at very large dosage of 300 to 400mg of lithium carbonate which has very low bioavailibility. On the other hand, lithium orotate has very high bioavailibility due to the orotate ions help lithium ions get into cells, especially in the brain. Thus, how much lithium ions in the blood and how long they stay becomes important.

I searched the lithium orotate half life in blood (hours of 50% of lithium ion still remaining in blood after introduction) and found 24 to 36 hours, however, long term use increases half life to 48 to 64 hours. Thus, I think it will be a good idea to take lithium orotate every other day or every third days in stead of every day.

I sincerely welcome any discussions on this subject.

@ralpha4 and others on this message string @oldelectrician

Regarding lithium orotate pharmacokinetics, dosing, safety, adverse effects, and beneficial effects - these are unknowns, see following.

Lithium orotate you may buy over the counter at health food store or from an internet source are not FDA approved. The only way the FDA will look at a product is if you have an adverse effect and report it or ask your doctor or pharmacist to report the product. Adverse effects reports will typically include the manufacturer, lot, and expiration. The FDA would determine what chemicals are in the product only after adverse effects are reported, not before. Pharmokinetic data on dissolution, absorption, half life in blood and brain, and similar parameters are reported to FDA for approved drugs, but your nutritional supplement is not an approved drug so I don't believe you will be able to obtain pharmaceutical data from the company of manufacture - although you could certainly ask - otherwise you can guess and hope what is on the label is accurate in addition.

Country of origin for lithium orotate may not be on your bottle. Many pharmaceuticals and nutritional supplements originate from India and China - costs may increase with tariffs.

As hdeff mentioned above, "it's a guessing game" right now. Guessing until such time as a known FDA approved and researched product is available.

I do encourage anyone experiencing adverse effects to take the effort to report to FDA, ask a pharmacist for help if you have trouble completing the online FDA adverse effects report. Sad to say some nutritional supplements aren't what they are supposed to be; to repeat the FDA doesn't sample nutritional supplements unless a problem is reported. It's also true lithium orotate may have unexpected effects - keep in mind use of lithium in the past 100 years has been primarily higher doses of lithium carbonate for serious conditions such as bipolar disorder. Use of lithium orotate in people without bipolar disorder is a guess, arguably an educated guess, and investigational.

Best wishes, hopefully no one trying a nutritional supplement has adverse effects, but reports to FDA if they do.

Thank you for this thoughtful look at Lithium orotate. How long before the blood half life increases to the extent you noted?

I just joinned, and I am delighted to participate in this forum. I have been reading AD literature for the last couple of years due to family history of ADs. I am not a physician or medical professional but was trained as a chemical engineer. I am going to start taking a very low dose of lithium orotate once I receive the shipment. Earlier today, I went through the recent Nature paper by Aron Liviu etal from Harvard and decided to explore this subject by some self-experimentation in a scientific way.
As we all know, safety is a paramont concern when taking any supplements so I searched low dose lithium long term toxicity in the medical literature but found little. There are well established renal toxicity when prescribed at very large dosage of 300 to 400mg of lithium carbonate which has very low bioavailibility. On the other hand, lithium orotate has very high bioavailibility due to the orotate ions help lithium ions get into cells, especially in the brain. Thus, how much lithium ions in the blood and how long they stay becomes important.

I searched the lithium orotate half life in blood (hours of 50% of lithium ion still remaining in blood after introduction) and found 24 to 36 hours, however, long term use increases half life to 48 to 64 hours. Thus, I think it will be a good idea to take lithium orotate every other day or every third days in stead of every day.

I sincerely welcome any discussions on this subject.