Squamous Cell Carcinomas (skin): What are the different treatments?

I have also had multiple Mohs surgeries on my lower legs for invasive squamous cell carcinomas but they keep returning and even growing and multiplying. I have tried topical chemotherapy using Fluorouracil Cream 5% daily and at times also intralesional injections with the same chemo therapy agent.
I have read that the intralesional injections should be repeated weekly or by weekly but I couldn't get an appointment sooner than a month from the last one. When I see the surgeon, they ask me what I want to do about them and since now I have 8 of them and living alone and want to keep being active, I feel that is way too many to do surgery on. I heard and read about SRT an other types of radiation. I am not sure which is the best option and could use some advise and recommendations from people who had the same or similar problems and dilemmas.
Thanks!

I have one sc on my face and am having the SRT on it, its very red they said I need 21 treatments, im on the 9th treatment, it lasts only about 2 or 3 minutes. They call it the gentle cure, I hope it works.
So sorry u hav so many. Prayers

I had a lower leg SCC excised May 2. Since then I've been receiving a pig placenta patch on a near weekly basis to promote healing, a somewhat new therapy. It's officially called an I-graft and was an alternative to a skin graft from my belly or upper arm: one surgical site, not two...all seemed to make good sense so I accepted my physician's opinion and went with it. However, I developed a staph infection at the end of May that required an ER visit and multiple rounds of antibiotics, understandably delaying my healing, which was originally projected to take about 6-8 wks. Now well into my 4th month of treatment, I would advise anyone to be well informed of the placenta patch. I've since learned it's wildly expensive (as a 74yo woman Medicare has paid) and recently learned that Medicare will pay for only 10 patches. I receive my final patch this coming Friday - an always painful process that requires an unanesthetized in-office debridement of the wound to permit a fresh place for the patch to 'take.' I am not fully healed and though the wound area is smaller than on May 2, it is still about the size of a nickel (as opposed to a quarter, originally). Not sure where I go from here, but it's been months of weekly therapy: generally painful, inconvenient (no water, no sand, a covered wound now being treated with medical grade honey). It's been a summer of no swimming, limited, difficult bathing or showering. Since the SCC is on the outside of my leg near the ankle, it's difficult to reach, but I'm lucky to have a retired veterinary surgeon hubby who cares for and changes my bandages and he's scrupulously clean and by-the-book. I've never had a skin graft so cannot compare, but this therapy has been no walk in the park and the results speak for themselves - at least in my case. I'd urge a very thorough discussion with any dermatologist recommending the pig placenta patch therapy. Though approved by our FDA, I understand that the procedure may be under review, though I cannot confirm this. I can only speak to my experience which has not been particularly positive. Perhaps I'm an aberration, but not based on a bit of googling (which I normally try to avoid). To add insult to injury, my Dr has grown somewhat testy, actually, and I fear our long term relationship (2018, malignant melanoma) has been personally affected. I maintain professional confidence in him, but at times feel as if he's begun to blame me for the lack of success, currently asking me about my diet, outlook on life, etc. He's clearly frustrated - but in a respectful way I told him there's plenty of that to go around at our last appointment. I know many, many folks are dealing with far worse situations and if it seems I'm whining, please forgive. I joined this group to share and learn and hope my experience can help guide others.

Did you have MOHS surgery? and then had more flare ups?

I don't know if I can help anyone else on this site but I'll add my experience just in case.
A tumor appeared on my forehead seemingly overnight. By happenstance, I was already going back to the Moh's surgeon for burning and curettage for a SSC on my arm when it appeared. (BTW, I don't recommend the "curettage and electrodesiccation" at all due to the extended period of healing and the very evident dime size scar. My skin doesn't heal well which may be a contributing factor.)
The surgeon did a "punch biopsy" which showed "an aggressive, rare, invasive, sarcomatoid-like SSC tumor wrapped around a large nerve bundle".

Since then I have had multiple oncologists appointments, a PET scan, a MOH's procedure to remove the tumor, a brain MRI, and an orbital MRI. I am grateful to say the scans have all returned negative for metastasis. Yesterday I was fitted with a mask and measured for the six weeks (30 treatments) of photon radiation prescribed by the radiological oncologist. Thursday I will be once again at my surgeon's office for another Moh's procedure on the top of my skull. It will be my fourth SSC surgery.

Finding this page about "reactive Squamous cell cancers" is at once fascinating and scary. You can bet I'm asking more questions and will share anything I think beneficial to the group.

FYI PostScript: The diagnosis I shared of the SSC tumor being "wrapped around a large nerve bundle" is also known as PNI: peri-neural invasion. It is one of the more alarming parts of the pathology as there is, as I understand it, a ready-made pathway for metastasis via the neural network. It portends a poor prognosis in most cases.

Please know my knowledge is significantly limited and any information I share is gleaned from a layman's understanding of scientific/medical information! I hope that's generally understood here!

@bwl8585: Thank you for reaching out to Mayo Clinic Connect to share your experience; we all learn a great deal from others and in turn, can get a great deal of support from others. I hope that is what you can gain from being part of our community.

First of all, I'm sorry to hear you had a difficult time with your ED&C (Electrodesiccation and Curettage) which is generally considered a minimally invasive procedure. I do see the typical informed consent does include wording to the effect of "discomfort, pain, bleeding, burns, electric shock, recurrence, conversion to excision, infection, changes in pigmentation, and scar" so there are those potentials. Personally speaking, I've undergone a number of these procedures for both BCC (basal cell carcinoma) and SCC, most recently this past summer and have not encountered any untoward effects. It's quite unfortunate this had been your outcome, yet it IS fortunate that it led to uncovering a more serious situation for which you're undergoing treatment. I wish you all the best with that. Can you please let me know from time to time how that treatment is going?

You're doing an excellent job of explaining! For more detailed explanation of PNIs, Mayo has this document, although not specific to the skin: https://www.mayoclinic.org/diseases-conditions/peripheral-nerve-tumors/symptoms-causes/syc-20355070