I have been completely transparent with my primary and neurologist that while I appreciate a conservative stance, I am not medically illiterate and simply do not have time to wait for for someone to get funding in this environment for full blown double blind human studies. In my case, I am 75 so time is critical. The multiple international longitudinal studies, NIH animal studies, and anecdotal evidence are good enough for me to give it a go. I am starting with 3 mg and intend to go to 5mg. Normal dosage for bipolar is 300-600 mg. So a 5mg dose is not a loaded gun providing I monitor eGFR and TSH levels- and both tests are a BAU part of my semiannual physical.
My diagnosis after NeuroPsych testing, specific blood work including genetic testing, and other imaging diagnostics are collectively termed Cognitive Impairment at this point. If I am to avoid the fate of so many in my family, I am availing myself of every option to slow the Alzheimer’s train. It is an extremely low dose supplement. If people were dying from it, we would know. I am trained in Neurophysiology so am confident if something goes south, I will recognize that. While I would prefer to partner with my Docs in this endeavor, I am nonetheless proceeding.
I so admire your proactive approach! We all need to research and be our own advocates. We are living in a time where medical staff are stretched to the max. I'm looking forward to hearing more about the results of this new treatment plan.
I so admire your proactive approach! We all need to research and be our own advocates. We are living in a time where medical staff are stretched to the max. I'm looking forward to hearing more about the results of this new treatment plan.
Thanks. I have to say that the odds on favorite outcome is zilch. I really don't expect any meaningful side effects at this dosage. My two primary symptoms are word retrieval challenges and losing focus/train of thought. A great result would be a slowing of those and other memory symptoms. Ask me in a couple of years what I think 🙂
Thanks. I have to say that the odds on favorite outcome is zilch. I really don't expect any meaningful side effects at this dosage. My two primary symptoms are word retrieval challenges and losing focus/train of thought. A great result would be a slowing of those and other memory symptoms. Ask me in a couple of years what I think 🙂
My wife has MCI and we are going to start lithium orotate at a 1 mg dose. Since research on this seems limited, and since there are no patents and big profits, it will be up to us to communicate and share whether there are any positive responses!
I've been taking 5mg/day of lithium orotate (Swansons) for a few years now.
Started after discovering the European longitudinal study that showed lower levels of degenerative brain disease correlated to higher levels of lithium in drinking water.
Lately there have been more positive results and suggestions of a possible mechanism.
No issues.
Theraputic doses of lithium for depression are a hundred or more times higher.
Life Extension has a 1 mg product if anyone is concerned about 5mg dose.
I was surprused to hear of lithium being used to retain memory.
I was prescribed lithium for over 5 years to "treat" cluster migraines. I have little memory recall of events during that time.
Was it the pain or the lithium?
I truly hope it helps you.
I just joinned, and I am delighted to participate in this forum. I have been reading AD literature for the last couple of years due to family history of ADs. I am not a physician or medical professional but was trained as a chemical engineer. I am going to start taking a very low dose of lithium orotate once I receive the shipment. Earlier today, I went through the recent Nature paper by Aron Liviu etal from Harvard and decided to explore this subject by some self-experimentation in a scientific way.
As we all know, safety is a paramont concern when taking any supplements so I searched low dose lithium long term toxicity in the medical literature but found little. There are well established renal toxicity when prescribed at very large dosage of 300 to 400mg of lithium carbonate which has very low bioavailibility. On the other hand, lithium orotate has very high bioavailibility due to the orotate ions help lithium ions get into cells, especially in the brain. Thus, how much lithium ions in the blood and how long they stay becomes important.
I searched the lithium orotate half life in blood (hours of 50% of lithium ion still remaining in blood after introduction) and found 24 to 36 hours, however, long term use increases half life to 48 to 64 hours. Thus, I think it will be a good idea to take lithium orotate every other day or every third days in stead of every day.
I sincerely welcome any discussions on this subject.
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@pb50
I so admire your proactive approach! We all need to research and be our own advocates. We are living in a time where medical staff are stretched to the max. I'm looking forward to hearing more about the results of this new treatment plan.
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4 ReactionsThanks. I have to say that the odds on favorite outcome is zilch. I really don't expect any meaningful side effects at this dosage. My two primary symptoms are word retrieval challenges and losing focus/train of thought. A great result would be a slowing of those and other memory symptoms. Ask me in a couple of years what I think 🙂
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3 ReactionsEven slowing down these symptoms would be great, @pb50! I applaud your courage and planning.
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3 ReactionsMany thanks!
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2 ReactionsGreat thing. Keep us updated
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2 ReactionsMy wife has MCI and we are going to start lithium orotate at a 1 mg dose. Since research on this seems limited, and since there are no patents and big profits, it will be up to us to communicate and share whether there are any positive responses!
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Hug
8 ReactionsDo you do any periodic check-up? TSH? Diabetes?
Thx!
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1 ReactionMy regular annual blood work always comes back OK.
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1 ReactionI was surprused to hear of lithium being used to retain memory.
I was prescribed lithium for over 5 years to "treat" cluster migraines. I have little memory recall of events during that time.
Was it the pain or the lithium?
I truly hope it helps you.
-
Like -
Helpful -
Hug
1 ReactionI just joinned, and I am delighted to participate in this forum. I have been reading AD literature for the last couple of years due to family history of ADs. I am not a physician or medical professional but was trained as a chemical engineer. I am going to start taking a very low dose of lithium orotate once I receive the shipment. Earlier today, I went through the recent Nature paper by Aron Liviu etal from Harvard and decided to explore this subject by some self-experimentation in a scientific way.
As we all know, safety is a paramont concern when taking any supplements so I searched low dose lithium long term toxicity in the medical literature but found little. There are well established renal toxicity when prescribed at very large dosage of 300 to 400mg of lithium carbonate which has very low bioavailibility. On the other hand, lithium orotate has very high bioavailibility due to the orotate ions help lithium ions get into cells, especially in the brain. Thus, how much lithium ions in the blood and how long they stay becomes important.
I searched the lithium orotate half life in blood (hours of 50% of lithium ion still remaining in blood after introduction) and found 24 to 36 hours, however, long term use increases half life to 48 to 64 hours. Thus, I think it will be a good idea to take lithium orotate every other day or every third days in stead of every day.
I sincerely welcome any discussions on this subject.
-
Like -
Helpful -
Hug
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