Can anyone share their experience with Pluvicto?

Posted by vcash @vcash, Apr 22, 2024

My 85 year old dad has prostate cancer that has metastasized to his bones. Zytiga is no longer effective. He is considering Pluvicto. I would appreciate input from those who have used Pluvicto.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Same here Jeff in terms of diet. I eat salmon about 2 times a week and the rest is like chicken, tuna, veggies and fruit. LOVE it!! 🙂

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Profile picture for eugenelapietra1 @eugenelapietra1

Hi Blane, Have someone drive you to your treatments and have them stay with you and take notes. Eat all your favorite junk foods. You do not want to lose weight. Don't let any negative BS enter your space. Shut the news off and watch comedies or listen to your music. If you have a pet keep them with you. You may or may not have some side effects, don't worry they'll pass quickly. This treatment is so much easier than chemo or radiation.You'll be happy you did it!!!Good luck, Gene

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Hi Blane, Jeff Marchi is totally misinformed. There's no Scientific evidence that pets are in danger. Clinical trials didn't include pets. I'm happy jeff didn't have any side effects from his 7 weeks I had over 100 radiation treatments with plenty of side effects. Bulking up is entirely different than putting on fat. You need the fat. Again everyone will have a unique experience. Don't let the negative experiences dictate yours. Good Luck , Gene

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Profile picture for eugenelapietra1 @eugenelapietra1

Hi Blane, Jeff Marchi is totally misinformed. There's no Scientific evidence that pets are in danger. Clinical trials didn't include pets. I'm happy jeff didn't have any side effects from his 7 weeks I had over 100 radiation treatments with plenty of side effects. Bulking up is entirely different than putting on fat. You need the fat. Again everyone will have a unique experience. Don't let the negative experiences dictate yours. Good Luck , Gene

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Pets are just a susceptible to radiation as people, Maybe even more so since their bodies are so small.

It’s pretty obvious you never even did a search of the web about whether or not you should be near your pets after being treated with Pluvicto because that would Show you that what I said is accurate.

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Profile picture for jeff Marchi @jeffmarc

Pets are just a susceptible to radiation as people, Maybe even more so since their bodies are so small.

It’s pretty obvious you never even did a search of the web about whether or not you should be near your pets after being treated with Pluvicto because that would Show you that what I said is accurate.

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Ok Jeff, Please cite which clinical trail says that. You'd have to share your bodily fluids with your pet to transfer any radio active material to your pets .check that out.On this forum the info we share must be accurate.

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Profile picture for eugenelapietra1 @eugenelapietra1

Ok Jeff, Please cite which clinical trail says that. You'd have to share your bodily fluids with your pet to transfer any radio active material to your pets .check that out.On this forum the info we share must be accurate.

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A quick web search shows this

Be mindful of contact: Limit close contact (less than 3 feet) with all household members, including pets, after each dose

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Profile picture for newby82 @newby82

Is there anyone at ages 80 plus that can share their experience with Pluvicto? How have their kidneys fared during the process and the extension of life worthwhile ?? thanks for any input and help as I am considering pluvicto. PSA is 111 and I have hormone resistant metastatic PC. Thank you

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I more that qualify and start LU 177 early Oct as it takes 2 weeks to come form USA NJ or new plant in Indianapolis In Canada its covered for over 65 and if you do ALL the tests Its in my bones only Pray for success They say it costs $27K per each of 6 injections

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Profile picture for eugenelapietra1 @eugenelapietra1

Ok Jeff, Please cite which clinical trail says that. You'd have to share your bodily fluids with your pet to transfer any radio active material to your pets .check that out.On this forum the info we share must be accurate.

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To eugenelapietrial:
I believe your basic knowledge of the science and understanding of radiation is way off. Pluvicto uses beta particle. Although the exchange of bodily fluids should avoided for a predetermined time after a Pluvicto treatment, this includes exhaling water vapor, saliva, urine, sweat, etc. But, as with all radioactive particles, the particles of beta, gamma, etc. travels through the atmosphere. That's the basics of a sunburn (UV radiation), a medical x-ray or CT, scan, the atomic bomb, etc. I carry a small geiger counter with me after each Pluvicto treatment and can easily see and hear the radiation levels being emitted from my body. No bodily fluids required. The radioactive particles are emitted through the skin.

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Profile picture for smc24 @smc24

To eugenelapietrial:
I believe your basic knowledge of the science and understanding of radiation is way off. Pluvicto uses beta particle. Although the exchange of bodily fluids should avoided for a predetermined time after a Pluvicto treatment, this includes exhaling water vapor, saliva, urine, sweat, etc. But, as with all radioactive particles, the particles of beta, gamma, etc. travels through the atmosphere. That's the basics of a sunburn (UV radiation), a medical x-ray or CT, scan, the atomic bomb, etc. I carry a small geiger counter with me after each Pluvicto treatment and can easily see and hear the radiation levels being emitted from my body. No bodily fluids required. The radioactive particles are emitted through the skin.

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Again I ask you to show me the clinical trails that mention pets, there are none. thats the science stop passing out misinformation

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Radiation was discovered 130 years ago and the scientists fully understand the positive and negative effects on animals and plants. You are correct, no clinical trials was performed specifically on "pets". Why would an institution spend hundres of millions of dollars to do so? We understand radiation. But, a pet is an animal and it's been know for a century the harm LU-177 can have.
I was one of the original Pluvicto clinical trial patients and hold multiple science degrees with 50 years of real life experience. You can do whatever you want, but raiation can be very helpful and deadly dangerous. It's basic physics, not "misinformation".

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Profile picture for jeff Marchi @jeffmarc

Be aware that 1/3 of people have really good results from Pluvicto, 1/3 Respond OK and 1/3 get nothing from it.

Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

Have you had a hereditary Test or a somatic test? It would be good to have both before having Pluvicto So you can see if you have a genetic conflict.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

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@jeffmarc
What if you have PTen and TP53 as well as ATM and BRCA?

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