Lupron: Anyone have muscle weakness and severe leg pain?

I am coming up on 7 months since Lupron injection and thankfully my leg pain during runs are just now reducing however I can’t say the same for the hot flashes. It does seem ,similar to yours every hour or so and when they occur I sweat enough for shirt to be wet. My wife believes they are reducing in occurrence but I haven’t noticed. Hopeful if legs are feeling better that soon these hot flashes will be gone. Knowing what ladies go through I really shouldn’t complain as some day mine will be gone. Best of luck, get healthy.

SUMMARY: Gleason 9, Group 5, with local spread as far as we know.

I am currently 54 (I started LUPRON at 52). I have been on Lupron and Abariterone (Zytiga) with prednisone for two years. I will be done in March with the Abariterone, but LUPRON will stay for at least another year or possibly life. This is the plan. I have constant leg pain ranging from 2 to 9, which makes it hard to walk long distances. I also have trouble climbing stairs. Most days, it's somewhere between 2 to 9.

I had an RP, and then six months later, cancer reoccurred, so I went through 35 rounds of radiation and ADT. Along with leg pain/weakness, I have days of extreme fatigue. I also have memory problems that cause me to stop mid-sentence to think of what I need to say next. It can be a challenge. I still walk at least a mile most days and do resistance training about 4 to 5 days a week.

Who knew Testosterone is such a critical chemical?

Hi. I'm 76. I have had significant "muscle wasting", too. This was before any treatments. I've had one Lupron shot and will start abiraterone within a few days when it arrives. Will take prednisone to offset the side effects (the damage ) of the abiraterone. Medical technology seems so primitive! I too was a walker, long distance, then however triggered, aggressive cancer hit, lesions multiplied. I must say, aspirin and celecoxib greatly help. I wish you the best.

90 days on Lupron for PC lymph node metastasis. Joint and muscle pain from hips down is unmistakable post injection. I have had CRPS in the right extremity (leg, foot) for 14 years. That pain is what I characterized as extreme. About 4 - 6 weeks into Lupron, the CRPS pain (I didn't think could worsen) became intensified and is now horrific! As I mentioned, the pain in the hips, muscles/joints in both legs is very real and all started after Lupron. Clearly a correlation. Causation, perhaps.

I have been getting cramps in my thighs almost every day night 🤷‍♂️

I get cramps in my calf’s

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

I see no one has answered you and all I can tell you is my experience as a nurse. We had a patient we gave monthly Lupron injections to. This was 40 years ago(nothing to do with prostate cancer) and I no longer remember the dose. One day he came inside and had a funny gait. Told me his leg hurt. This guy rode his bicycle all over. Very active. I looked at his leg and sent him to the ER. He ended up having blood clots-2 in his leg. The psychiatrist took him off the Lupron citing that as the cause and he never had another Lupron injection.
This is something you should talk with your Dr about. Chances are it’s nothing but, if you think you might have blood clots you should be seen ASAP. I don’t want to scare you but I also don’t want a clot to break loose. They can do an easy Ultrasound and let you know. I wish you well.

Thank you. I see my doctor in two weeks and will definitely discuss. In the meantime heating pad and massage can bring some relief.

The side effect of muscle loss has made my legs do the same with less. I particularly noticed it in my thighs. Might be the same for you. Still it is wise to bring it up with your doc. Best to you on your journey…