Prolia infusion and BE flare afterwards

I just did a search for infections related to Prolia and it looks like there is a small risk of increased serious infections. SAEI=Serious adverse events of infection.
A Canadian review of studies in 2021 by Catton concluded: "Conclusion: Denosumab-treated patients with low bone mineral density have slightly increased incidence of SAEI compared with placebo, but not when compared with bisphosphonates. Application of these results requires consideration of the entire body of data available regarding denosumab safety."

There's a more recent study from Taiwan also indicating a small increase in infections.

I didn't see any with just bronchiectasis. Given the info, I'd discuss it with your doc to decide risk/benefit. Good luck to you

Is anyone doing the Reclast infusions, and if so have you had any increase in exacerbations with it?

I was diagnosed with bronchiectasis in 2012. Started Prolia in 2023. So far, I have not had any serious infections. If you have not received flu, RSV and Covid boosters, discuss with your Dr.
I took a Mediterranean cruise six months before starting Prolia and caught RSV before the vax was available. I was hospitalized for 7 days. When the RSV vax became available 3 months later I took it.

Thank you. I am current on all my shots.

I sure hope I have made the right decision. I decided not to start Evenity. For me after reading the possible side affects I decided I am not going to take it. My thoughts and decision was arrived at due to possibly having to start antibiotics down the way for the BE, and further as well, the fact that one must go on another type of medication for the bone density problem after the period of taking Evenity. I could not tolerate Fosamax, Actonel, Forteo in earlier years.
I have fallen at least three time in the last decade and so far no broken bones.. My bone density is -4 and has continually gone down since the early 90's. I realize everyone is different due to many life and health factors.
At nearly 83 I hope I made the right decision........ only time will tell.
Barbara

Thank you for this discussion. I am undecided about Prolia which was recommended recently by an endocrinologist. I have had osteoporosis for 20 yrs, and more recently injected Forteo for 2 yrs. I am 75 diagnosed with bronchiectasis & MAC nearly 8 yrs ago after hemoptysis landed me in the hospital. I have been very fortunate as the regular hemoptysis ended after I started nebulizing 7% sodium chloride. What worries me most about Prolia is it “may increase your risk of developing infections” . So far I have stayed mostly well on this 8 yr. journey! I’d welcome the experience or comments by any others who have taken Prolia. I am a Mayo patient & will be sending a note to my pulmonary Dr. this week. Take care all. Linda

I’m am the same situation, finding an osteoporosis med that will not interfere with my BE, which is pretty well controlled. Any info would be helpful.

Following, I have been asked to go to Prolia from Fosamax. In addition to the rebound issues, am also wondering how this could impact lung health short term and long term.

Thank you for this discussion. I have been taking prolia every six months for 5 years. I also have BE and NTM/MAC diagnosed in 2012. Until about 2022 I was doing ok but started getting flares and MAC was more apparent. This past year though the flares have been more frequent and this winter I struggled either s UTI and now pseudomonas in lungs so was denied a prolia infusion until i am well. I am taking tobramycin nebulizing and have a week to go. I inquired re an alternative to prolia. My endocrinologist is bluntly adamant that taking prolia is fine because it is given to cancer patients in even higher doses. Yet pseudomonas aer. is a bacteria. A complicating factor is that ehen I took fosamax about 2000 I developed hives only when running and therefore sweating and only on my back. It would seem unwise to take prolia while infected. I would dearly love to talk with someone who understands my dilemma. .