@ray666 That's a tough decision to make. High risk MDS has more severe treatment options with a shorter survivability. I hope the Dr discussed the prognosis. How much time does the Dr say your partner has with each treatment option? How long does she have before AML is diagnosed. Chemo will definitely affect her Quality of life. Transfusions help people feel better but will probably be frequent for high risk MDS. I think Decitabine is available for High Risk Patients. It is available in pill form. You could ask the Dr if any oral treatments are available and how much time it will buy your partner.