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Low WBC, Low Platelets, Low RBC, Large cells - is it always Leukemia?

Blood Cancers & Disorders | Last Active: Sep 23 6:01pm | Replies (94)
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@asarnesejr You are on a rollercoaster! Those are vastly different diagnoses. You wondered why you had varying CBC results. I am not a Dr, but my results have varied especially if I was sick and possibly on other meds. A Dr can tell you why the variations. I do not understand the different diagnoses. The counts you posted originally were like a mirror of my own at different points. What did the FISH results show. It is important that you see a Hematologist who is also an Oncologist. If you can be seen by a a Hem/Onc at an MDS Center of Excellence that's even better. Did the 2nd Dr see the results of the BMB? Hem/Oncs don't pursue a BMB unless there is cause. Centers of Excellence: https://www.mds-foundation.org/community/centers-of-excellence/browse/?country=US

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Replies to "@asarnesejr You are on a rollercoaster! Those are vastly different diagnoses. You wondered why you had..."
asarnesejr | @asarnesejr | Aug 30 11:06am

hi again. Both doctors are Hematologist/Oncologist. Just two different hospitals.

To recap: initial routine blood test: B12 153, WBC 1.6, ANC .6, MCV 106, Platelets 65.
No blast cells in red blood, 2% blast cells in bone marrow, large red blood cells in bone marrow. FISH results were negative. No symptoms, feel fine.

Doctor #1: B12 is not low enough to cause these issues. Is either Leukemia or MDS. Bone Marrow Biopsy next morning. After 3 weekly B12 injections (from my primary doctor) he concluded low-risk MDS (before my FISH results were returned). Ordered 6 weekly blood CBC blood tests.

Doctor #2: B12 is low enough to mimic the MDS symptoms. 3-weeks of weekly B12 injections are not enough. Stopped weekly blood tests. Weekly blood samples could lower my hemoglobin levels. He is Skeptical of the Diagnosis. Ordered me for 6 more weeks of weekly B12 injections, no blood tests till September 16th.

What are your thoughts on all of this? Will I know on the 16th if it's cancer or just B12 issue?

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