Are you already on Prolia? If you are, you have to take something if you quit, otherwise you will lose not only any progress you made, but will be worse off than before you started. I read a study that this will happen at about the 6 month mark, the bone loss. In that same study they said fosamax/alendronate was a good alternative if you were quitting Prolia. I have been on Prolia for 5 years, so 10 injections. No discernable side effects. Three weeks ago my health organization switched to Jubbonti, which has the same active ingredient as Prolia. I have had terrible side effects. Burning nose, chest pain, but the worst was the bladder inflammation. I was in bed one day alternating advil, tylenol, with a heating pad on my abdomen. I was treated for a uti just in case that was part of the bladder inflammation equation. I am blaming the drug Jubbonti, which has only been on the market for 2 months. I have already informed my doctor that unless I get an exception, approval for Prolia, I won't be having another injection. In all fairness, maybe it wasn't the new drug, Jubbonti, per se, but rather maybe after 5 years on Prolia/Jubbonti (denosumab) my immune system isn't what it used to be an therefore I had the bladder issue. I am considering not getting another injection in 6 months. Trying to figure it out, where I go from here. I did read a study from the National Institutes of Health that fosamax/alendronate, is an option if one quits Prolia and better than risedronate(actonel).