Experience with Donanemab and Lecanemab

I hope the med helps your wife. I don’t have any info on either of them, but wanted to say that my father who had Alzheimer’s took two of the traditional meds for it. They were a great help as we tried reducing them once with negative results. Best wishes with everything.

My wife has now had 12 doses of Lequimbi and the infusion process is not bad at all. Her first time was a little rough with headaches but we now take a tylenol prior to the infusion and have lengthened the process to 1.5 hours. Her Neurologist just had his first patient finish the 1.5 year long process and is very encouraged with the results. We take the infusion at a local clinic with no issues so not doing it at the Mayo shouldn't be an issue. I wish you every success.

My husband takes Leqembi and has not had any side effects from it. The problem that I have is the neurologist always asks if I see an improvement. I can’t really answer that because I don’t know how he would be now if he hadn’t taken the infusion. He has had treatments since January of 2025 every other week. He is more forgetful but he could be worse if he hadn’t taken the not taken the drug. This journey is very hard and I have to constantly check my patience.

My mom was offered the treatment but my dad declined because of possible brain bleeds. I see his point.

Thanks for your input. Treatment or not is clearly not an easy decision.

Just finished infusion #17. After #16 I had the same blood test that diagnosed AZ. Results show a substantial drop in both categories. Little or no complications. Male, 74

@jgestey, how often do you get infusions? How are you doing?

@jgestey

Thanks for your comment. I just had my first infusion n two days ago so very new to the "journey"

I'm curious about the blood test you took that indicated improvement. What are the two categories? Maureen

My husband has had 4 monthly infusions of Kisunla so far and has no after effects whatsoever. He does have a reaction initially (gets very hot, flushed when infusion is started, but they stop it, add something like Benadryl or Pepcid to the infusion and restart it in a few minutes and he's fine! We have spoken with a woman who just completed 18 months of it and she feels it has made a huge difference. Don't delay making the decision because it's my understanding that it's only indicated in the early stages of Alzheimer's and after a certain point they won't give it to you.

@theglobalnomad1, I wish there was more information to the public about the new treatment options for Alz. After caregiving 2 family members with dementia…I would highly encourage considering it. Despite potential side effects…..dementia is so brutal….