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Profile picture for pauladiamante @pauladiamante

A chart is good for that specific info. I agree. Bisphosphonate following Evenety.. my question is for a specific issue. It's the cause of the osteoporosis has been treated. Tumors were removed Jan 2024 that were tearing up my bones. So I figure, if the evenety did its job I shouldn't be in any worse shape than any other healthy person in my age group.... I mean I'm pretty active, I work out. Weight lifting.. wild animal rehab ... I still can't figure out why I need to be medicated. Regardless of the medications mechanism of action. I AM an MD. But not an endocrinologist. And I have a hard time trusting opinion....

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Replies to "A chart is good for that specific info. I agree. Bisphosphonate following Evenety.. my question is..."

Hi @pauladiamante, when was the CTX result (285) taken? If that was your baseline before any treatment, then your bone resorption is on the lower side. But if it was measured while you're on Evenity, that would sense since evenity suppresses bone resorption, so this CTX reading is expected.

I've read that for people with very low baseline bone turnover, some endos may choose to use a lower dose (I've come across 1/2 dose of fosamax - 35mg/wkly) of bisphosphonate to help "lock-in" the bmd gains after an anabolic treatment. So basically some form of antiresorptive therapy is still needed after an anabolic even if your true baseline CTX is very low. In this case, you could taper off the antiresorptive therapy over time with careful monitoring.

That said, oral form of bisphosphonates such as fosamax or actonel are usually easier to adjust in terms of dosing. Smaller dose of iv zolendronate is an alternative. Personally, I don't see how you could taper off Prolia without transitioning to a bisphosphonate, unless you've only had one dose. Even then, your resorption ( as indicated by CTX) is likely to go up once that dose wears off, then returns to your baseline after a period of time. You may or maynot have some degree of bone loss during this period.