I take only atorvastatin and apixaban, and those are for risk to keep my chances of clotting and arterial blockage low. When I was fibrillating, I was on ever-increasing doses of metoprolol, but I never took bisoprolol and have not read much about it. The fact is that each of us is unique in how we respond to any kind of intervention, be it therapy or medication. Some do well on flecainide, some do poorly. Some can be successfully put onto Dofetilide while others cannot take it. Statins are okay for many, a great many, but it is well known that they cause all sorts of problems, chiefly sore muscles and joints, in some patients. So, all that to say you may indeed not be tolerating your combo well, and you should let your prescribing authority know, or at least your druggist/pharmacist...they can be very helpful.