Prolia treatment for osteoporosis: What is your experience?

If you stop Prolia, there is no choice at this point in time, other than Reclast (the strongest) or alendronate. Prolia has a rebound and you can lose bone density and have increased fracture risk very quickly, according to my doctors, Dr. Ben Leder's YouTube video "Combinations and Sequencing", McCormick's book "Great Bones" and many other sources (just citing my favorites). Reclast or alendronate are needed after every other osteoporosis medicine, actually, to "lock in" gains, but it is especially important after Prolia due to the strong rebound. Maybe you could do a bisphosphonate for one year (one Reclast for instance)-????

It may be as simple as one Reclast infusion but I don't know how long you need bisphosphonates to counter the rebound. McCormick and some doctors will use the CRX bone marker test to monitor when the bisphosphonate is needed, exactly (timing of infusion for instance) and also how you are doing with the rebound risk. For instance if you did one Reclast, the CTX could be done to make sure it is working and then the CTX could be done months later, and continue as a monitoring approach evaluating whether more bisphosphonate is needed. But there may be a standard answer to this already. It's just that you might want to do less alendronate or Reclast because of prior use.

I don't know if there is any research into other sequences after Prolia but I have not seen any. Always ask your doctor! Generally bisphosphonates are taken 3-5 years.. Prolia is also an anti-resorptive. So you have only been on anti-resorptive. I think a situation like yours is complex and needs medical advice. Do you have a good endocrinologist?

Elizabeth, may I ask how old you are. I am 76 a d my endocrinologist wants me to start prolia after I finish Evenity in several months
I have already had alendronate a d forteo
If I start prolia now and want to get off what can I follow it with..

I took forteo for two years then alendronate for 5. Now on my 11th shots of evenity and my endocrinologist wants me on prolia. Thanks

@sungal some are staying on Prolia 8-10 years apparently but for those of us in our 70's, that means into our 80's and then stopping and doing Reclast....When I am 80+ I would consider Prolia if it was tolerable and if the effect on immune system is okayed by research and MD's (I have lupus). I have a friend who is 83 and taking it for the rest of her life, apparently. She has not been told about a need to stop or rebound and follow-up and I did not enlighten her 🙂

I experienced sudden and significant hair loss after my third shot.
Also my fingernails have become tissue paper thin.
I am waiting to see a specialist to find out what I should be taking alternatively.
Needless to say, I quit the Prolia shots.

Doctors are universal in denying Prolia side effects. My gastroenterologist told me that he has a number of patients who are on Prolia and experiencing gastrointestinal issues

I was on Bonviva for 2 years and it didn't work. I started Prolia in January. So far the only side effects I notice are the same I had with Bonviva... stiffness in my hips and knees when I sit for a long time or first thing in the morning. I am 53 and have just started testing to see if they can discover a cause for my Osteoporosis.