What treatments have helped or not for generalize granuloma annulare?

After 1 year of multiple treatments with no positive results I was referred to a more specialized Dermotologist. He's prescribed a JAX inhibitor ointment Tofacitinib 2. I'll use 2Xs/day for 4 months. I've been at it for 1 week so far and no improvement. Got a while to go.

I used the same dermatologist fir 1 1/2 year after a biopsy proved GA. He "wasn't sure" how to treat it and for that time I was prescribed ointments, antibiotics etc. Finally, he referred me to another dermo who dismissed all previous treatments as focused on JAX inhibitor in ointment form. I'll let you know if it helps in 3-4 months.

I have had GA for 20 years. It started with just a few small lesions on my knees and elbows. My derm treated me with steroid creams and then steroid injections which combined seemed to work. 5 years later the lesions were all over my body- too many to continue with the steroid treatments. I started on Humeria (not FDA approved treatment for GA) and it completely cleared the GA! Then in 2020 I broke out head to toe with some type of Eczema, which was awful. Painful, extremely itchy oozing sores everywhere. I started on Dupixent injections which completely cleared the eczema. I was still taking the Humeria for the GA so I was on 2 biologic injectables but my skin was clear and no side effects. I had blood work done every 6 months to monitor for any side effects and all was good. In 2024 my husband changed employment along with our insurance and the new insurance company declined declined declined authorization for me to take both medications. I made the decision to go off the Humeria because the worse of the two was facing the horrible conditions of Eczema. After stopping the Humeria, my GA came back slowly but soon was all over my body again. My derm did some research and found a case where a woman was treated with Rinvoq for extreme GA and it cleared. We decided to try it and since it is FDA approved for Eczema, I went off the Dupixent and started ocean’s day pill of Rinvoq. Within two weeks not only did it work for the eczema it completely cleared my GA!! (Rinvoq unfortunately is not FDA approved for GA). But it should be!!! Hope this helps someone

Thank you!
I've been applying tofacitinib ointment 2 X's daily for 3 month and can't determine if it is (very slowly) working or the GA is diminished on it's own. Recently, I've noticed more dime-size GA appearing on my legs and arms. I return to Dr in a month. I'll ask about Rinvoq.

I'm 51 and diagnosed with GA at ten years old. Went into remission when pregnant three times, but it became invasive in my late 30s into my 40s. Hydroxychloroquine is the only treatment that put me in remission outside of my pregnancies in my 20s and early 30s (tried creams, meds and nothing all prior). I was in remission for three years thanks to Hydroxychloroquine before I got Covid the first time in 2020 and it came back within that month. I have tried two separate, three-month interval Hydroxychloroquine treatments with no results. I had Covid two more times since 2020, too. The Covid has something to do with my not being able to go into remission, it's obvious, but nonetheless, I hope you tried Hydroxychloroquine since your original post last year and have had positive results. It's a shame more has not been done with GA treatments, but the attention to something non-threatening doesn't get a spotlight.

I have had this for 5 years and I went gluten free so mine is better now. But anytime now I eat something gluten it comes back. See if that helps

A

@helenruss
Hello,
This past summer I noticed the bumps starting on my hands and face at first I thought it was a allergy due to me being on dupixant for almost 4 years for severe atopic dermatitis. They started to spread i went to dermotologist by August and they did a biopsy on my hand and it was positive for GA, I have tried steroids creams everyone without success, tried injections in my hands and that worked for about 70% of tgem on my hands,they continued to spread. My dermotologist started me on Hydrochlorquine 250 mg daily but the nausea side effect was unbearable so cut the dose in half and was on it for about a month with lesions only spreading, start chloroquine daily and uvb photo light therapy 3x a week without success, went to a second opinion at a bigger dermotologist clinic they put me on methotrexate 2.5 MG once a week and Vitiman supplement rest of days and im continuing the chloroquine and light treatment as well with regular blood draws due to risks of these medicines, they also stopped me on dupixant the second dermotologist has a suspicion thats what caused mine. I hope you get relief soon, I am hopeful I will be following up with my local dermotologist monthly and my 2nd dermotologist every 3 months my next visit at end of April should be showing some relief if not alot I have been told. The lesions on my face itch terribly.

@springer1961
How long do your lesions last and with or without treatment?

@anandx
Hello,
Can I ask which treatments you tried and for how long?