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Best answer: ask your doctor. Next best: arthritis is a disease of the joints, while MM (a disease of the bone marrow) generally damages, well, bones with marrow. Those are the long bones of the arms and legs and flat bones such as the pelvis and sternum. Gray zone: your back. Your spine is a series of joints, but the vertebrae do contain some marrow.

So pain in joints is likely arthritis, especially in older folks. Persistent pain mid-shaft in an arm or leg - in other words, not elbow, knee, ankle or wrist - in any MGUS, SMM, or MM patient should immediately be reported.

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Replies to "Best answer: ask your doctor. Next best: arthritis is a disease of the joints, while MM..."

I wish I could have gotten such a succinct answer from my doctor. Thank you!

This is nearly exactly what my MM specialist told me. I’m to report such pain asap.

@wesleym Thank You! I really would have benefited from this information 3 years ago! After 20 years of MGUS and being told to report bone pain I did still not have this much clarity on the subject- but knew I had to press on for a more complete diagnosis. I now am thinking I may have reported elbow or knee pain when it was the long bone near those areas. Did persist for diagnosis and recently started treatment for Multiple Myeloma and Amyloidosis.