That just sounds crazy about the cognitive damage part. I have found the estradiol only gives me energy and if I miss a dose I'm tired without it and I notice it!, It gives me a boost to get through the day! I do need to get on the progesterone though as I am not on that part and I know it will enhance the other. We never got around to adding it and it's been a couple of years. My urologist originally suggested I go back on it to my gyno. for recurrent infection and irritation. "Senior bladder" issues.