ANA test follow up results - anyone else experience this

My heart aches for you. Personally, I would see another Rheumatoloigst for another evaluation/consult. Your body had built up antibodies against itself. So identify the SOURCE of those antibodies.

I understand sero-negative RA. My late husband had this. His x-rays looked like mice had been eating away at his bones in his toes and hands. He had so much pain. May he rest in piece. All the steroids and Humira finally took their toll on his body.

Hi saw2019,

You and I share the same titre of 320, and a speckled pattern. Since having been on Plaquenil (2018) my titre now falls within the near normal range. My high anti-CCP readings have turned negative. I still suffer with Sjogren’s symptoms, although no anti-SSA or -SSB antibodies are present. Never had any elevated inflammatory markers. The searing episodes of hand pain are gone, just some mild wrist and hand pain from time to time. The original diagnosis of Mixed Connective Tissue Disease (MCTD) was changed to Undifferentiated Connective Tissue Disease (UCTD), and here I remain!
Autoimmune disease is a very strange journey, and quite changeable. Symptoms and lab results come and go. I think the earlier you start treatment, the better the outcome. And don’t ignore diet and staying active. Look into alternative treatments. Above all, be prepared to get second, third, even fourth opinions. And good luck!

This was helpful to read, I've had similar test results. My rheumatologist has described it as inflammation that is active in different parts of the body at different times and so I think the fluctuation in test results is due to the variable nature of where and what is being attacked or damaged.

I have a speckled Ana.
Diagnosis Lupus, Sjogrens, Hashimotos (autoimmune hypothyroidism), mixed connective tissue disease,
I also have autoimmune severe axonal sensorimotor peripheral polyneuropathy, small fiber neuropathy
Dysautonomia, cardiac autonomic neuropathy. I am between stage 4 and 5 on neuropathy.

Overview
Antinuclear Factor (ANF), Antinuclear Antibody (ANA) and Its ...
In the context of an Antinuclear Antibody (ANA) test, a speckled pattern indicates the presence of antibodies targeting various extractable nuclear antigens (ENAs) within the cell nucleus. This pattern is commonly seen in autoimmune diseases like Systemic Lupus Erythematosus (SLE), Sjögren's syndrome, and Mixed Connective Tissue Disease (MCTD). However, it can also appear in healthy individuals, making it a non-specific finding that requires further clinical evaluation

Hi,
Sorry to hear about all the different health challenges. I also right after Covid shot I had allergic reactions & myocardial infarction & then started having multiple health issues but no one was able to diagnose the issues. I finally found a GP that took the correct tests & was diagnosed with Lupus, Hashimotos then later fibromyalgia and the worst nightmare one polyneuropathy .
I'm on hydroxycloriquone, steroids, cymbalta 60mgs and lyrica 300mg daily . Helps take the edge off the symptoms but sometimes the medication doesn't work and now I have extreme brain fog or who knows what else? Sometimes I'm at a loss for words mid sentence forgot my best friends name. Rheumatologist suggested I see neurologist but prior to seeing rheumatologist I was seeing neurologist and he told me he couldn't help me anymore & see someone else. So many doctors and no one is able to help me. I feel useless , I was so energetic and was able to accomplish so much . Now work is becoming challenging as well . Not sure what I will do next ??

I've had LS for about 20 years. Took forever to get the Dx, because until I went to Mayo Clinic for a spine follow up and they asked if anything else was wrong, I explained the cuts and feeling of being cut, and numerous misdiagnoses of yeast and vague results of "inflammation" did they take a look and biopsy with results of LS. Also have oral lichen planus. Now I learn one of the likely causes of repeated UTI's is the thinning skin not protecting my vulva,bladder, etc so keep it well covered with a barrier, ladies! I had to postpone cervical spinal surgery 4 times due to active and now colonized UTI's - our gyno's and derma's don't know or don't tell us this! I learned on my own through extensive searching pubmed, etc.

Do you know if lichen planus can cause Ana titer to be mildly positive? My sed rate, CRP, CK, CCP, labs are all normal but ana titer is 1:160.

I don't know.. only understand that any auto immune disease can cause labs show positive titers.