New antidepressant: Has anyone tried Auvelity?

Posted by csmiller @csmiller, Oct 26, 2022

Anyone know the name of new antidepressant, approved by FDA, that's supposed to be available at end of this year?

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My friend's doctor recommended Auvelity instead of a combination of Buspar, wellbutrin and Trintelix?
Should she give it a try?

REPLY
@eliza56

My friend's doctor recommended Auvelity instead of a combination of Buspar, wellbutrin and Trintelix?
Should she give it a try?

Jump to this post

I have never heard of Auvelity or Trintelix. I would love to know about them.
I welcome anyone with information to post it.

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@divinewisdom28

Auvelity. It's a combination of Wellbutrin and dextromorphin. I'm trying to get it prescribed.

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Wouldn't it be a lot cheaper to just take generic Wellbutrin and buy DXM over-the-counter in a cough medicine?

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@daveshaw

I have never heard of Auvelity or Trintelix. I would love to know about them.
I welcome anyone with information to post it.

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My friend swear by Trintelix, She had been on it for a decade and different dosages. Started by itself 5 mg then 10 mg. Then her doctor increased it to 20 mg and her doctor added welbutrin 150 mg. The combination worked very well for almost 1 year.
Tapering off of it and takes only 150 wellbutrin for 2 months.
She started getting worse and the doctor put her on 300 mg for another 4 months without any antipderesent.
All the problems started especially her ringing of the ear. 2 ear specialist prescribed some xnaax and felt much better but stopped 6 weeks.
She got worse,
She started feeling better with taking Trintelix 20 mg, buspar15 mg and wellbutrin 300 for a while.
She felt better for six weeks, but had to reduce Trintelix to 10 mg bc it makes her not be able to cry when she needs to!

REPLY
@eliza56

My friend swear by Trintelix, She had been on it for a decade and different dosages. Started by itself 5 mg then 10 mg. Then her doctor increased it to 20 mg and her doctor added welbutrin 150 mg. The combination worked very well for almost 1 year.
Tapering off of it and takes only 150 wellbutrin for 2 months.
She started getting worse and the doctor put her on 300 mg for another 4 months without any antipderesent.
All the problems started especially her ringing of the ear. 2 ear specialist prescribed some xnaax and felt much better but stopped 6 weeks.
She got worse,
She started feeling better with taking Trintelix 20 mg, buspar15 mg and wellbutrin 300 for a while.
She felt better for six weeks, but had to reduce Trintelix to 10 mg bc it makes her not be able to cry when she needs to!

Jump to this post

Now the question is should she switch from the combination to Auvelity????

REPLY
@eliza56

My friend swear by Trintelix, She had been on it for a decade and different dosages. Started by itself 5 mg then 10 mg. Then her doctor increased it to 20 mg and her doctor added welbutrin 150 mg. The combination worked very well for almost 1 year.
Tapering off of it and takes only 150 wellbutrin for 2 months.
She started getting worse and the doctor put her on 300 mg for another 4 months without any antipderesent.
All the problems started especially her ringing of the ear. 2 ear specialist prescribed some xnaax and felt much better but stopped 6 weeks.
She got worse,
She started feeling better with taking Trintelix 20 mg, buspar15 mg and wellbutrin 300 for a while.
She felt better for six weeks, but had to reduce Trintelix to 10 mg bc it makes her not be able to cry when she needs to!

Jump to this post

Thanks for the answer.
Why doesn’t she try Zoloft or another SSRI along with Wellbutrin. They work very well in combination and at one point they had a nickname “welloft”. Buspar could also give her more relief and clonazepam could help with anxiety.
I know there are “haters” out there regarding any benzodiazepines and yes I know they are addictive. That being said if you never increase your dosage and use them responsibly they can have a positive effect especially for those suffering from acute anxiety.
Many claim withdrawal is very difficult and it is but so is withdrawal from things such as alcohol, nicotine and sugar among other things. Some say withdrawal from nicotine is worth that withdrawal from heroin.
I recently talked to a nurse who gave up smoking and started vaping. She said because of the amount of nicotine that is in vaping it has been harder to quit vaping than it was to quit smoking.
If you have severe anxiety don’t rule out responsible use of a benzo. Unlike opioids I have never heard of someone dying from taking a benzo. Just be responsible and don't increase your dosage.
Good luck to you.

REPLY
@eliza56

Now the question is should she switch from the combination to Auvelity????

Jump to this post

I had a good experience with it in 2023. I was feeling really good but I got sick and 2 of my doctors said to stop it cuz it could be that causing symptoms but it wasn’t. Here I am 2.5 yrs later still sick and I asked my doctor if I could go back on it and a week in I’m already feeling it kick in again. Talk to your doctor and give it a try. I’m very optimistic!

REPLY
@daveshaw

Thanks for the answer.
Why doesn’t she try Zoloft or another SSRI along with Wellbutrin. They work very well in combination and at one point they had a nickname “welloft”. Buspar could also give her more relief and clonazepam could help with anxiety.
I know there are “haters” out there regarding any benzodiazepines and yes I know they are addictive. That being said if you never increase your dosage and use them responsibly they can have a positive effect especially for those suffering from acute anxiety.
Many claim withdrawal is very difficult and it is but so is withdrawal from things such as alcohol, nicotine and sugar among other things. Some say withdrawal from nicotine is worth that withdrawal from heroin.
I recently talked to a nurse who gave up smoking and started vaping. She said because of the amount of nicotine that is in vaping it has been harder to quit vaping than it was to quit smoking.
If you have severe anxiety don’t rule out responsible use of a benzo. Unlike opioids I have never heard of someone dying from taking a benzo. Just be responsible and don't increase your dosage.
Good luck to you.

Jump to this post

I agree about what you said that the benzo works very well with SSRI when used responsibly with a doctor.
But people including some pharmacists need to be educated more about it with the combination with other medicine. By many studies, the SSRI needs to be combined with Benzo.
But stigma about benzo use with the doctor administration and prescription needs to be changed.

REPLY
@rhonda1965

I had a good experience with it in 2023. I was feeling really good but I got sick and 2 of my doctors said to stop it cuz it could be that causing symptoms but it wasn’t. Here I am 2.5 yrs later still sick and I asked my doctor if I could go back on it and a week in I’m already feeling it kick in again. Talk to your doctor and give it a try. I’m very optimistic!

Jump to this post

Welcome to the group and thank you for your post. My issues after surgery
is very high anxiety and, depression. Just coming in after being in the
brain tumor group. No I have not tired the med.

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