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I also take Synthroid for thyroid every morning around 8:30. I eat a late breakfast and wait until 12:30 to take HU. Have you been told to have 12 hrs between thyroid meds and HU? My sister takes her thyroid meds before bed but she eats an early dinner and likes to eat breakfast immediately and not wait the hour. I guess I might have to rethink my plan also. Main question is how long to wait to take HU after Synthroid? I might have to push it to mid-afternoon. Oncologists don't seem to know this issue so will have to ask endocrinologist.

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I started Hydroxyurea 7/05/25 500mg daily. Very mild side effects including short episodes of hot flashes, a tiny hint of nausea a few times, and two episodes of fatigue. After napping a few hours I felt much better following g the fatigue. My dose was just increased to 1,000 mg daily due to increased platelets. A bone marrow biopsy is scheduled three days from now.
I am trying to eat very little processed foods, am drinking a lot of water, and jogging in the pool for an hour every day. Hopefully these efforts may be helping to minimize side effects 🤷‍♀️

I have taken my Synthroid for years first thing in the morning and always at least an hour before eating. When I started 1000mg of HU about five years ago, hematologist suggested I take the HU at night before bed in order to minimize side effects. She knew I was on Synthroid and never mentioned it in that discussion. I can’t say I’ve ever been nauseous and attributed it to the HU. So, there’s at least an 8 hr gap between HU and Synthroid.