High Triglycerides - How can the number come down

Thank you for the reply. Unfortunately statins are not lowering my triglyceride number.

Stains for most do lower triglycerides - here is an AI summary.

"AI Overview
Yes, statins can lower triglyceride levels, particularly in individuals with hypertriglyceridemia (high levels of triglycerides). While statins are primarily known for lowering LDL cholesterol, they also have a beneficial effect on triglycerides by reducing VLDL (very low-density lipoprotein) triglycerides.
Here's a more detailed explanation:
Statins and LDL Cholesterol:
Statins work by inhibiting an enzyme in the liver that is crucial for cholesterol production. This leads to an increase in the number of LDL receptors on liver cells, which in turn removes LDL cholesterol from the bloodstream.
Statins and Triglycerides:
Although their primary mechanism focuses on cholesterol, statins also impact triglyceride levels. They reduce the production of VLDL, which carries triglycerides, leading to a decrease in their levels in the blood.
Effectiveness:
The extent of triglyceride reduction with statins depends on the individual's baseline triglyceride levels. Studies show that statins can lower triglycerides by 20-40% in patients with hypertriglyceridemia, according to AAFP.
Combination Therapy:
In some cases, individuals with very high triglycerides may require additional medications alongside statins, such as fibrates or omega-3 fatty acids, to further manage their triglyceride levels, notes Medscape.
Clinical Significance:
Elevated triglyceride levels are a risk factor for cardiovascular disease, and managing them alongside LDL cholesterol is important for reducing overall cardiovascular risk. "

Thank you for your reply. Wishing that statins could be effective in my case.

Lots of different types - some folks find success with one, but not the others. Ask your doc? An AI summary ...

"Statins are a class of medications used to lower cholesterol levels and reduce the risk of cardiovascular disease. Several types of statins are available, including atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor).
Commonly prescribed statins:
Atorvastatin (Lipitor):
.
A widely used statin known for its effectiveness in lowering LDL cholesterol.
Rosuvastatin (Crestor):
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Another potent statin, often preferred for its ability to significantly reduce LDL cholesterol.
Simvastatin (Zocor):
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A commonly prescribed statin, available in both generic and brand name versions.
Pravastatin (Pravachol):
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A hydrophilic statin, often considered for individuals with certain health conditions or those who may be more sensitive to side effects from other statins.
Lovastatin (Mevacor):
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One of the earliest statins, available in both immediate-release and extended-release forms.
Fluvastatin (Lescol):
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A statin with a shorter half-life, often taken once or twice daily.
Pitavastatin (Livalo):
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A newer statin, known for its ability to lower LDL cholesterol and triglycerides.
Key Considerations:
Intensity:
Statins vary in their potency, with atorvastatin and rosuvastatin generally considered the most potent.
Solubility:
Statins can be classified as lipophilic (fat-soluble) or hydrophilic (water-soluble). Lipophilic statins can enter cells more easily, while hydrophilic statins are more concentrated in the liver.
Individual Needs:
The best statin for a particular individual depends on various factors, including their cholesterol levels, other health conditions, and potential side effects.
Side Effects:
While generally safe, statins can cause side effects like muscle pain, digestive issues, and, in rare cases, liver problems.
Combination Therapy:
Statins may be combined with other cholesterol-lowering medications to achieve optimal results.
Lifestyle Modifications:
Statins are most effective when combined with a healthy lifestyle, including a balanced diet and regular exercise."

Thank you.

Not all statin drugs work the same way. I was on Prevastatin for many years. My triglycerides were always elevated. Rosuvastatin by Crestor is a very different statin drug. Talk to your doctor. lDL cholesterol for the first time was in the normal levels. All my numbers were normal.

@deniseheart
I think I posted before about fish oil. My heart failure doctor directed me to take fish oil twice a day. This is in addition to taking Astorstatin (spell). Like you I had high tryglicerides also along with LDL high.

I see some have posted about fish oil not being effective on tryglicerides. I can only post my expererience with this wiht my heart failure doctor putting me on it. My tryglicerides were cut in half. This me so does not mean would have same effect on you but you can asked your doctors about it.

My wife had high tryglicerides (she is on a statin also) and her PCP put her on fish oil also. So it seems my Mayo doctors believe it is beneficial. As always when added supplements best to check with your doctors to make sure okay for you to add.

thank you!

Here's an AI summary re efficacy of fish vs the synthetic - not discussed at length is that the synthetic Icosapent Ethyl (Vascepa) has production standards and is regulated, while fish oil could, in some cases be from anywhere, with zero certification or regulation of contents.

"Icosapent ethyl (Vascepa) is generally more effective than standard fish oil supplements in reducing triglycerides, especially in patients with very high triglyceride levels or those at high risk for cardiovascular events. While both contain omega-3 fatty acids, icosapent ethyl is a purified form of EPA (eicosapentaenoic acid) and is specifically formulated to lower triglycerides without raising LDL-cholesterol levels.
Here's a more detailed explanation:
Icosapent ethyl (Vascepa):
This is a prescription medication containing only EPA in an ethyl ester form. Studies, like REDUCE-IT, have shown that it can significantly reduce triglyceride levels and cardiovascular events in high-risk patients, even those already on statin therapy.
Fish oil supplements:
Most fish oil supplements contain both EPA and DHA (docosahexaenoic acid). While they can also lower triglycerides, they may also increase LDL-cholesterol levels in some individuals. Additionally, the quality and purity of over-the-counter fish oil supplements can vary, and they may not be as potent as icosapent ethyl.
Efficacy:
Icosapent ethyl is specifically formulated and dosed to achieve a more pronounced triglyceride-lowering effect, particularly in patients with very high triglyceride levels (≥500 mg/dL). Studies suggest that icosapent ethyl can reduce triglycerides by 30% or more, while standard fish oil may have a more modest effect.
Cardiovascular risk reduction:
Beyond triglyceride lowering, icosapent ethyl has demonstrated a reduction in cardiovascular events in high-risk patients. This benefit is attributed to its ability to reduce inflammation and improve other lipid parameters.
Considerations:
While icosapent ethyl is generally well-tolerated, it's essential to discuss its use with a healthcare professional, especially if you have existing medical conditions or are taking other medications. Some studies have indicated a slightly higher risk of bleeding with icosapent ethyl, but this is generally rare."

Lots of info. Thank you!