Can anyone share their experience with Pluvicto?

What was your experience with Pluvicto?

I’ve never had it. I’ve been to quite a few online conferences where they spend an hour on it. A few people over at Ancan.org Weekly advanced prostate cancer meetings, have had it and discuss side effects.

My husband had six Pluvicto infusions over most of 2024 and had none of the severe side effects that some people experience. He had some fatigue, a dry mouth from his saliva glands being affected by the treatment, and his appetite for food decreased in that most things just didn't appeal to him. His last Pluvicto infusion was in August 2024, and the only side effect remaining is dry mouth. Please don't worry about the radioactivity warnings; your doctor or treatment staff should tell you what is necessary, and it is much less than the overkill that some men do. No need to buy a Geiger counter or totally isolate yourself for days! Congratulations on starting Pluvicto, and good luck to you.

I had to go back and review my nuclear protocols. Just to make sure. All those years on Nuke subs, at least we joked when we said "when they turn off the lights, I glow in the dark!"
Did you know with Pluvicto some folks promote Geiger counters and pocket dosimeters? A tad overkill with a short half-life.
Some folks say 30-day half-life, looking up Lutetium 177, half life is 6.65 days. Fits into 2-3 feet from children for 6-7 days.
Right now, with the majority of Docetaxel out of my system, been doing yard work. Been a long time.

Yeah, we'd researched that 1/3-1/3-1/3 bit. I am ATM.
Anymore, don't trust the science. Just go with the flow and see what happens.
Had two of those genetic tests. Two different results.

You could have had two different somatic tests, Or you had a hereditary test and a somatic test. The cancer can cause the somatic DNA test to change, So you can have a different result after a test run some time after the previous test.

Could have. All things are possible, but not probable.

Promise/Color, oh, you're good, not hereditary, don't have to inform kids.

1.5-2 years later,things don't seem to be following "the plan", onc sent sample off to a lab in Chicago.
Just so you might clearly understand, this was not a NEW biopsy sample, this was a bit of the ORIGINAL biopsy sample.
I suppose sitting in a refrigerated space all that time, the DNA in the sample could have transcended earthly bounds and become something else for the next test.

Nah.

Ooooops. New lab says it IS hereditary, and oh, by the way, it's ATM variant.....and then the onc changed "the plan" because those meds were not best for ATM.

Doesn't matter.
I don't trust medical professionals any more.

79 years young with metastacized Prostate Cancer in my ribs & backbone. I also have IPF. I have been dealing with the cancer for 4 plus years. Chemo, ADT, direct radiation to the prostate, and now I"ve had two rounds of Pluvicto. Side effects: tiredness (to add to the effect from all the meds), dry mouth, increasing discomfort in my bowels, and a gnawing question about whether its working. My doc won't do another PSMA scan till after the 4th treatment which is frustrating - only way to know if its working or not. No pain from injection - hassle keeping distance from my wife and sleeping in separate rooms ( we like each other) but the tiredness increases and I wonder about other side effects. Thought it good news (at least for the drug company) that they have now approved it for use without chemo or ADT - the idea is great and hope its working and killing the cancer cells. Choose life, fight, fight, fight.

My oncology team, Lynn Cancer Institute in Boca Raton, watches various blood indicators carefully to tell what/how the Pluvicto injections are behaving. I'm told that platelets, thyroid and kidney functions are among the closely monitored indicators. And, can't forget PSA direction but it seems that early on in the injection series you can expect to see the PSA turn up. Hope others can provide more info.

I am 86 and will have my 4th Pluvicto infusion today 6/26/2025.
I had 9 treatments of Chemo. The PSA started out at
86 and got down to 7. Chemo was a real bitch. Then after 11 months the PSA was back up to 80 and I started Pluvicto. My PSA has dropped like a rock. 80 to 40, then 40 to 13 and now 13 to 5.5.
My side effects have been minimum. Way better than chemo.
I am one of the lucky ones that Pluvicto works on!

Willis Beavers