Anyone have experience with amiodorone as an arrhythmia treatment?

Posted by insley @insley, May 14, 2024

I’ve had almost 2 years of treatment for PVCs. Two ablation treatments failed to resolve these extra beats and left me with RBBB. Flecainide (100mg 2x/day) provides considerable relief but I still have periods of symptomatic PVCs nearly every day. My EP has suggested starting a course of amiodorone. Anyone have experience with amiodorone after Flecainide?

Interested in more discussions like this? Go to the Heart Rhythm Conditions Support Group.

I was on IV Amiodarone for 24 hours recently while in cardiac ICU. AF had been managed effectively by Sotalol for 2+ years but it was triggered by MI (caused by SCAD, spontaneous coronary artery dissection) and cardiac arrest. Cardiologist wanted to get HR down as fast as possible, given the risks of further dissection. It worked and now I am back on Sotalol, not really tolerating it either and may have to consider ablation when and if it is safe to do so. EP says wait a few months and revisit the question. There are no great options!

REPLY

With tachycardia at 134 BPM for 72 straight hours, and nothing seeming able to stop it, I was sent to the ER and given Amiodaron by IV. It worked almost instantly! It was fascinating to watch my HR on the screen dropping 2-3 bpm every couple of seconds. I loved Amiodarone for keeping my heartbeat under control for the next year. Then my Cardiologist weaned me off of it "because it's such a powerrful drug." Went to Metoprolol after that which has been great as well. Have been able to double my physical workouts w/o suffering any symptoms so far.

REPLY
@insley

Why did you go off amio? FWIW I tried sotalol while in hospital after an ablation that got complicated. It lowered my RHR to below 30bpm which greatly disrupted my sleep.

Jump to this post

My EP took me off due to the toxicity of it. Sotalol is a safer alternative. To be fair, I was first on Sotalol, but it led to shocks from my ICD, so I wanted something more effective. Amiodarone is what I got and it worked well. I eased into the Sotalol after my ablation and have been good since.

REPLY

Was on 200mg twice a day a week before my cardioversion. Stayed on it for about three weeks later until my ablation. The day of my ablation, my EP took me off it. I do feel it was helpful. At a minimum, it gave me a mental sense of security that I’d maintain sinus rhythm until ablation. I do feel it caused some side effects though. Mainly dropping my heartbeat to 40 bpm. Was still on 50mg metoprolol too. After ablation, my beat holds steady between 60-65 resting. Both my cardiologist and ED (and I) wanted it to be very short term. I realize everyone is different but surprised to hear of the use of anti arrhythmic drugs after ablation.

REPLY

Thanks, your comments are informative.

REPLY

I’d like to comment on my experience
with Eliquis. Three days after I started on Eliquis I broke out in a rash which was limited to my face and neck. It wasn’t t painful but it itched a bit. I saw both a GP and a dermatologist and both said there was no connection to Eliquis. This continued for 6 months and my cardiologist was concerned and acceded to my request to change from Eliquis to Xarelto. The rash started to go away slowly and in about two months was gone. Has anyone else had this experience?

REPLY
@gloaming

You can read about amiordarone if you google the correct syntax. It's pretty much the biggest hammer there is for arrhythmias. It's also quite toxic, and has to be carefully monitored.

The way it usually works is that there is initially a 'loading dose' of between 600 and 800 mg for about a week. That means two potent tablets each day for a week. Then, you go on a maintenance dose that might be weight-dependent, not sure about that, but in my case if was 400 mg, so 200 mg BID. Depending on your condition, and its recent treatment (in my case it was a week after my first, or index, ablation, and I went into intractable and rapid AF), I kept the maintenance dose for three weeks, after which I was to taper with a single 200 mg tablet PO for two more weeks. Your prescription might be considerably longer for reasons I don't know.

The drug really works. I wasn't keen to begin taking it, but the alternative was AF upwards of 180 bpm. Nobody can live at that rate for long, so amiodarone it was. It is potentially dangerous for the lungs and for the kidneys, as examples, so the ideal strategy would be to maintain you on the drug until you can be corrected via catheter ablation or a pacemaker, or some other strategy that will allow your heart to function quasi-normally without it.

Jump to this post

And.... the correct spelling is AMIODARONE (and not Amiordarone) !

REPLY
@cblouin234

And.... the correct spelling is AMIODARONE (and not Amiordarone) !

Jump to this post

Thanks for pointing that out. Typo. Fat fingers.

REPLY

I took amiodarone for several years. I didn’t seem to suffer any side effects, but my EP took me off it and started me on a combination of flecainide and metoprolol. I’ve been using them both for about 4 years now, and they work quite well. I’ve only had two fairly brief episodes of a-fib, each only lasted a few hours.

REPLY

Thanks for all of the comments about Amiodarone. My cardiologist wanted me to start taking it on June 5th, but after reading 4 pages of side effects listed in the MedGuide that involved kidneys, thyroid, eyes, skin, intestines, additional heart issues, etc... I was very concerned and told him I was not taking it. A recent heart Cath procedure showed no more blockages after my triple by-pass surgery, however, I have heart PVC and atrial & ventricular tachycardia. I have another appt scheduled with him in 2 weeks. I may discuss a lower dose for a short period of time or the other drugs than some of you mentioned. The cardiologist has mentioned a defibrillator implant to address my heart issues and wanted me to be on the drug for a month. Still not sure about taking the drug. I have no chest pain or some of the other symptoms...but have had a few dizzy spells and a few palpitations. A Holter Monitor picked up the PVC and Tachycardia. Not sure what is the best decision will be.

REPLY
Please sign in or register to post a reply.