@num1boxer1919: I so understand the trying different anti-depressants and having adverse effects. And, for me, I really got tired of hearing, "well, these (the medicines) work for MOST people" - 'most' being the key word here. Since we aren't 'most' people, that is small comfort isn't it? I agree that being both wired and sick are horrible feelings. Since you've tried several different remedies, I'm wondering who is prescribing them - is it a general practitioner or a mental health specialist? My regular doctor is a wonderful and knowledgeable man, but he also knew when he was operating outside his area of expertise, and so he referred me to someone whose specialty was mental health issues. Also, I've learned that my pharmacist is often my best resource when it comes to trying something new - they often know about a drug's properties to a greater degree than a doctor does, or they understand the interactions with one drug and another. I've often asked them when I start taking something new if it is in the same family or type of drug as others I've tried that didn't work. If so, I know that 1) I need to start out with 1/2 of the dosage recommended by the doctor since many drugs are too strong for me at the outset, and 2) while I don't ask for the pharmacist for advice about what to take, since that is the doctor's job, I do ask them about other drugs that may be in a different category. For example, after trying several anti-depressants and anti-anxiety drugs, many of which were in the the SSRI's classification, I learned (from the Sleep Center doctor at Mayo) that Wellbutrin was the only one that wouldn't exacerbate my restless leg syndrome. Once I started taking that, my depression and anxiety lessened considerably, and it has now leveled off and manageable. Also, not sleeping creates its own level of anxiety and inability to function, which can be depressing too. I'm wondering if it is possible you are taking some medications that might be interacting with each other, or if you are trying some that are all in the same category or classification. It sounds like you are almost apologetic about feeling stressed, and I don't think you have anything to apologize for - if you are feeling that bad, are not sleeping, feel anxious and depressed, then you do have valid concerns and need to find a partners (doctors, pharmacists, therapists, etc.) who will work with you to find the answers you need. . . and keep trying until together you find something that works. Good luck!