I was diagnosed in March 2023 when I mentioned in an annual appointment that I was having some numbness in one of my feet. A med student was assisting the doctor and ran every blood test imaginable! And MGUS showed up. After 6 months on circumin my Mspike actually disappeared but my doctor was firm in saying that it was not gone forever and that it would always go up (and hopefully) down over time. SIx months later (on my blood draw last month) the M spike was back where it had been a year ago but the doctor was not surprised or concerned. Hard to know if it would have been higher without the circumin so I am going to stay on it!