@kim1965 your comment/question brought me back to shakier times in my early post liver transplant experience. Did your wife experience shaking pre transplant, and/or episodes of hepatic encephalopathy? I did in spades, and post transplant I was alarmed that the shakiness was worse and lasted for several months. When I said, ‘enough’ to my team 3-4 months out, they shared that they could change me to a different formulation of tacrolimus (my primary immunosuppressant) that was extended release. They would need to appeal to insurance to cover it, as it’s much pricier and I said ok. However during this process the shakes subsided on their own. Somewhere in there my prednisone was dialed down and discontinued which may have related to my improvement. Who knows why. It’s so hard to experience that and I know that on some level it troubled my family more- they thought I was in pain. I hated having trouble writing, texting, cooking, maintaining balance, falling asleep but it did improve. Perhaps there is a better medicine formulation for your wife, or maybe her body is still adjusting/recovering. We are on powerful medications, especially in the first 6 months-1 year. Please share how this unfolds- I think this is an important topic especially within the first year of transplant. I never thought I’d stop shaking, I accepted it as my lot in life and now it’s a distant memory 3.5 years out. Likely it will be for you and your wife. Keep us posted!