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Prolia Side Effect: Edema

Osteoporosis & Bone Health | Last Active: Dec 23, 2025 | Replies (33)

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Profile picture for sylviacarol @sylviacarol

I had my first Prolia I he ton two weeks ago. The nurse said I could expect some tiredness for a few days, but nothing more. Within a day every joint in my entire body ached, I was nauseous, my ankles were swelling, and I had a headache. Although I am out and about, I feel terrible and have been told these side effects could last for weeks. I will not have another injection.

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Replies to "I had my first Prolia I he ton two weeks ago. The nurse said I could..."

My 1st shot in April. My hair started falling out. Some low back bone pain. Now edema. I'm a thin person & suddenly my weight started going up. My cholesterol way up, A1C up. I'm allergic to stains & keep my numbers down with plant based diet. All this from Prolia. Now I have racing heart. Don't know if that's
Related to Prolia but have excellent health up til now. I'm not taking another injection of Prolia. Just Mt good diet & Pilates twice a week.

@sylviacarol
Saw many drs due to severe 10 pain in ankles involving foot, toes and up to femor. No answer. Took another 6 mo shot BINGO!!!Prolia shot. Extremely bad pain now in both feet and left leg. Nausea and hair loss. Cannot walk sleep etc. Never should have gone past 19 th shot.