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Cretastimogene Grenadenorepvec: Anyone in the PIVOT-006 Study?

Posted by nihifam4 @nihifam4, Mar 29 10:00am

Husband has had 5 Transurethral Resections of Bladder Tumor (TUBT) since 1999. Tumors low-grade cancer until now. Last surgery 5 tumors, high-grade cancer. The doctor wants him to do this Randomized Study of Adjuvant Cretostimogene Grenadenorepvec versus observation for the treatment of intermediate risk non-muscle bladder Cancer. Is anyone in this study?

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fmfran | @fmfran | May 27 6:59pm

Thanks. I’m still waiting on my results from my BCG. Can I enroll now or do I have to show that the BCG did not work..
Fran

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djr5 | @djr5 | May 31 11:51am
In reply to @sparkyconnect "Just enrolled in trial last week at Mayo Jax Initial treatment to start in approx 3..." + (show)
@sparkyconnect

Just enrolled in trial last week at Mayo Jax
Initial treatment to start in approx 3 wks

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I wish you the best, and hope you are included in the initial teratment arm of the study. Please consider posting about your ongoing experiences with the trial and, I sincerely wish, the successful results.

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fmfran | @fmfran | May 31 6:52pm
In reply to @sparkyconnect "I just enrolled in the trial at Mayo Jax. Scheduled for randomization in approx 3 weeks...." + (show)
@sparkyconnect

I just enrolled in the trial at Mayo Jax.
Scheduled for randomization in approx 3 weeks. Hopefully will be in the initial treatment arm of the study. Everything I have researched suggests this may a breakthrough treatment.

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What is the protocol? Is it put in the bladder like the other treatments? How many and how often?
Thank you
Fran

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1 reply
vejan738 | @vejan738 | Jun 2 12:19pm
In reply to @djr5 "Hello, I was diagnosed low grade NIMBC in December 2023, had TURBT, Mitomycin and a course..." + (show)
@djr5

Hello,

I was diagnosed low grade NIMBC in December 2023, had TURBT, Mitomycin and a course of BCG.
The dctor found high grade NIMBC cardinoma in situ in January 2025, and I had an intravesical treatment of Adstiladrin in March. I have a cystopscopy scheduled for June 4th and I will know if I've achieved a complete response. I'm 70 years old. I had not heard of Cretostimogene prior to Fred's posting. I am thinking ahead, in the event that the Adstiladrin doesn't work. I'm trying to learn more about neobladders, which facility and physicians are best at the procedure, and - now - whether it would be a good choice to try Cretostimogene as a preliminary option, before surgery. I am in Omaha, Nebraska. Did you have to make application to participate in the Cretostimogene program? Was it something your doctor suggested? I'd appreciate any information you may have to share.

Dave

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headed for treatment with Adstiladrin within 2 weeks, 2 TURBT's tested lesions and came back positive. The cost for this new drug is out of this world but trials have really been promising

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1 reply
djr5 | @djr5 | Jun 2 3:07pm
In reply to @vejan738 "headed for treatment with Adstiladrin within 2 weeks, 2 TURBT's tested lesions and came back positive...." + (show)
@vejan738

headed for treatment with Adstiladrin within 2 weeks, 2 TURBT's tested lesions and came back positive. The cost for this new drug is out of this world but trials have really been promising

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I hope all goes well for you. You may want to bring a book or music/earphones to the treatment. Once it is administered, you have to stay on the table for an hour. Godspeed!

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sparkyconnect | @sparkyconnect | Jun 3 4:45am
In reply to @fmfran "What is the protocol? Is it put in the bladder like the other treatments? How many..." + (show)
@fmfran

What is the protocol? Is it put in the bladder like the other treatments? How many and how often?
Thank you
Fran

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Trial info is available at CG Oncology website.
Very informative

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