Can weight gain cause progression from MGUS to myeloma?

Posted by amyboylan1 @amyboylan1, May 13 11:25am

I have been diagnosed with MGUS. I have read that weight gain can cause progression from MGUS to MM. I’ve gained quite a bit I think due to the anti depressants and food cravings. I’m so upset with myself. Please tell me about any experience or information you have about this. I’m would greatly appreciate it. I have my six month blood check in a few weeks and am very concerned. Thank you, Amy

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The plant based diet with added tumeric and omega 3 lowered my IgG kappa 0.2

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@8positive

The plant based diet with added tumeric and omega 3 lowered my IgG kappa 0.2

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Be carful Tumeric can stop absorption of iron severely. It was a great anti inflammatory substitute instead of IB but I need iron lol

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@8positive

The plant based diet with added tumeric and omega 3 lowered my IgG kappa 0.2

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Sorry, but you don't know that. You know that, after following the "plant based diet" for an unspecified period of time, your IgG k went down. Things like IgG k fluctuate normally. You can't assume a causal relationship.

In other words, post hoc ergo propter hoc is a logical fallacy. The jury is still out on the effectiveness of turmeric and a vegetarian diet.

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@mattymatilda

Hi. I have all of these and they are all abnormal or out of range. My last Dr. said I shouldn't worry because they fluctuate. I am not on any special diet I just try and eat healthy. I lost 17 pounds but it didn't affect these numbers. I'm curious about your question, too.

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I lost 26lbs since August and my numbers still went up. Just had a BMB and see them hemanoc in a couple weeks.

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@nypara66

Be carful Tumeric can stop absorption of iron severely. It was a great anti inflammatory substitute instead of IB but I need iron lol

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Most people with MGUS also have a form of anemia. I am IDA

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@dmdinapoli81

Most people with MGUS also have a form of anemia. I am IDA

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Yes. I have chronic anemia.

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@wesleym

Sorry, but you don't know that. You know that, after following the "plant based diet" for an unspecified period of time, your IgG k went down. Things like IgG k fluctuate normally. You can't assume a causal relationship.

In other words, post hoc ergo propter hoc is a logical fallacy. The jury is still out on the effectiveness of turmeric and a vegetarian diet.

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So true. And I love the Latin phrase, I’m going to save it and use it in future. Because of my anemia/iron deficiency, I don’t eat vegetarian. But I have added occasional tumeric supplement because I have read positive benefits for MGUS. I know the studies aren’t conclusive but they are suggestive. It probably boils down to good nutrition helps a strong immune system which may help slow, but doesn’t cure progression. We can hope, and we know there is a strong connection with body and mind.

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I emailed an author of the 2017 paper "Long-term follow-up of curcumin treated MGUS/SMM patients – an updated single centre experience".
He emailed me with his website http://www.mgustherapy.com and also that the curcumin he used in their clinical studies was C3 complex from Sabinsa.
My reading of the studies is that the type of MGUS may make a difference. It appears that curcumin is not too effective for my IgM MGUS as other types. I will continue taking it until my next test and then decide.

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@dcuste

I emailed an author of the 2017 paper "Long-term follow-up of curcumin treated MGUS/SMM patients – an updated single centre experience".
He emailed me with his website http://www.mgustherapy.com and also that the curcumin he used in their clinical studies was C3 complex from Sabinsa.
My reading of the studies is that the type of MGUS may make a difference. It appears that curcumin is not too effective for my IgM MGUS as other types. I will continue taking it until my next test and then decide.

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Folks - you gotta read this stuff carefully. Taking the "studies" listed on this site in order by year:
2024: Sample size 1. Yes, 1.
2020: studied use of cucurmin in place of steroid (usually dex) to ameliorate effects of standard MM drug regimen in those already diagnosed.
2017: Sample size 6.
2017(2): sample size 13.
2017(3): same study as 2017(2).
2016: sample size 10 (MGUS cohort).
2015(1): sample size, CLL (chronic lymphocytic leukemia) patients 21; MGUS patients 0
2015(2): another CLL study; sample size 21
2015(3): sample size 1
2013: in vitro study.
2013(2): sample size 2
2012: the only double-blind placebo-controlled study of the group. Sample size: 36. Conclusion: "These findings suggest that curcumin might have the potential to slow the disease process in patients with MGUS and SMM." Note "suggest", "might" and "potential".
2011: Nothing to do with curcumin (or any other supplement).
2010: Vitamin D deficiency may increase damage MM does to bones. No kidding. Vitamin D is vital to bone health independent of MM.
2009: sample size 26.
All tiny, all equivocal, only one double-blind. I'm not suggesting that someone who - after consulting with physician - wants to take cucurmin should not do so. In the quantities discussed here, it is not likely to do any damage, other than potentially to iron absorption. I have high-risk MGUS / SMM, and know how you want to DO SOMETHING. But you have to read between the lines before getting your hopes up, especially on sites where - as here - they want to sell you stuff.

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@amberl99

So true. And I love the Latin phrase, I’m going to save it and use it in future. Because of my anemia/iron deficiency, I don’t eat vegetarian. But I have added occasional tumeric supplement because I have read positive benefits for MGUS. I know the studies aren’t conclusive but they are suggestive. It probably boils down to good nutrition helps a strong immune system which may help slow, but doesn’t cure progression. We can hope, and we know there is a strong connection with body and mind.

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You are right there are a lot of things this body can do

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