I can’t comment on why your gradient might have increased but will share my experience. I’m 76, female and started on 5mg Camzyos 2 years ago. My gradient was 150ish. Within days I felt better - more energy, less angina. But my gradient barely moved. I increased dose to 10mg. Felt even better but after a few months gradient barely decreased. Doctor urged me to have surgery. Instead, I arranged for pharmacogenetic test which showed I was a rapid metabolizer of Camzyos. I asked to have dose increase to 15mg. I had no side effects. Within three months my gradient dropped dramatically. It is now normal. Long may it last! It’s worth exploring how you metabolize Camzyos. I was told this is routinely done in the UK and China before prescribing. Wishing you all the best.