As promised, my successful tapering off Effexor (Venlafaxine)
Below you will find the tapering plan that I used to successfully wean myself off Effexor (Venlafaxine). Feel free to share this with your doctor If you would like. I researched and came up with this plan, which was approved by my doctor, although she thought I could probably have weaned myself off sooner. But the reality is that we all have differing tolerance levels for tapering and weaning off this powerful drug from our bodies. Some people can taper faster, but usually not those who have been on this drug for years (like myself, since October 2002). I tapered off EffexorXR 150mg capsules about 5 years ago down to 75mg, and was on that maintenance dosage for a couple of years until I started weaning off the 75mg a year ago in April 2019. As of October, 2029, I’ve been withdrawal symptom free, but I still have occasional periods of anxiety when triggered. But I realize these waves of anxiety will soon pass, and I cope by deep breathing, taking a walk, having a cup of chamomile tea, etc. Cutting my exposure to watching upsetting news has really helped a lot as well. These days I seek things that bring joy and peace in such a turbulent world. Wishing you all a successful weaning off this powerful drug.
Weaning off Venlafaxine XR 75mg (Effexor-(extended release)capsules:
Weaning plan off plan that worked for BSS:
1. Inform your doctor you are tapering down from 75 mg Venlafaxine and ask them to prescribe 37.50 tabs to help with tapering doses (1/2 dosage down from 75 mg Venlafaxine capsules). The tabs are easier to cut into halves and quarter dosages than counting out beads from the capsules.
2. Begin your taper only after you are on a non-withdrawal symptomatic dosage level. If you were having w/d symptoms at 75 mg, you’ll need to go back to the level at which you were symptomless and stay there for 2-3 weeks before deceasing to a slow taper. NOTE: after successfully tapering from 150mg Venlafaxine down to 75mg for a month, I was unable to tolerate a drop cold turkey from a daily dosage of 75mg down to 37.50mg (50%) without having bothersome withdrawal symptoms of dizziness, brain fog, brain zaps, and nausea. So after researching various tapering plans, I came up with a slower tapering schedule my body could tolerate to finish the tapering from 75mg to 37.50mg, and then on to complete the tapering. Your body may even need slower tapering, so adjust according.
3. Week 1-2: Take 75mg caps MWFSu; take 37.50mg tab on alternate days Tu,Th, Sa. At the end of week 2, if you only have relatively mild to no withdrawal symptoms, proceed to week 3. IMPORTANT: If you have intolerable symptoms, adjust to a slower tapering schedule by adding an additional 1/2 tab on the alternate days (or take a total of one and a half 37.50 tabs on alternate days). You’ll then have to tweak the rest of your tapering schedule. If all goes well, proceed with week 3.
4. Week 3-4: Cut a few 37.50 tabs in half with a pill cutter or exacto knife blade to create quarter pieces. Take 37.50mg tab on MWFSu and take 3/4 tab on alternate days Tu, Th, Sa.
5. Week 5-6: Take 3/4 of a tab MWFSu, and take 1/2 tab on alternate days Tu, Th, Sa. If only mild symptoms, proceed to week 5.
6. Week 7-8: Take 1/2 tab on MWFSu; and take 1/4 tab on alternate days Tu, Th, Sa. If no symptoms, continue to week 7.
7. Week 9-10: Take 1/4 tab on MWFSu; and take 1/8 tab (cut 1/4 tabs in half) on alternate days Tu, Th, Sa. *Notice the quartering of doses into crumbs now...very important to keep small dosage tapering to remain withdrawal symptom free.
8. Week 11-12: Take 1/8 tab crumb on MWFSu; take none on alternate days Tu, Th, Sa. *If skipping alternate days produces symptoms, stay on 1/8 tab crumbs for a couple of weeks before alternating skip days for a couple of weeks.
You’ll find that this schedule may have to be tweaked for you by extending the time you stay on a taper...possibly up to 3-4 weeks before beginning a new tapering down. It all depends on how you tolerate the first two weeks.
Interested in more discussions like this? Go to the Depression & Anxiety Support Group.
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1 ReactionThank you. I’ll check that out.
I am hoping to get off Effexor for good this year. I originally went on it for hot flashes, but I liked how I was not so scattered. The one side effect that I can't stand is the weight gain.
I applaud you successfully tapering off Effexor but I also wonder if you truly suffered from depression.
Depression is genetic and if you truly suffered from it you will always suffer from it.
Exercise is a great way to help deal with depression but that alone will not make it go away.
For anyone reading this post who truly suffers from depression you know what I am talking about. Find a drug or drugs that work and keep taking them.
Much like there is no cure for alcoholism there is no cure from depression. Rather it is how you choose to deal with it.
This person who posted how she weaned off Effexor didn’t really suffer from depression. Those that do suffer from depression know that and know what happens when you stop taking your antidepressants.
This comes from someone who does suffer from depression and successfully treats it.
Good luck to all of you who truly suffer from depression.
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1 Reactionthanks i am just starting .tappering from 150 mm of venalflexen er to 75 .first week was ok but sec is harder aniexty and gi problems ,but i will keep going.
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2 ReactionsYou might consider going more slowly to avoid some of these withdrawal symptoms. I recommend you take a look at what Dr. Mark Horowitz has to say in his book Deprescribing Antidepressants.
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1 ReactionMe too!
I have been prescribed liquid form for part of it so I can make minimal reductions and I shall be very gradual
Very best wishes.
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1 Reaction2029 has not happened yet. As I read this, it is still May of 2025.
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Hi, I am currently been on Venlafaxine 75mg since 2016 and feel I have done enough work on myself to manage without them. Going to go with your tapering suggestions. A little scared to come off as been told my depression and anxiety could be an imbalance of chemicals in the brain. Recent studies show this to be unlikely. My dad has been on meds since 18 and so have I on and off. Thinking my memory issues could be down to long term use? Anyone else feel memory is an issue? Or it could be down to age/ menopausal symptoms. I am 48.
Will be seeking GP advice but appointment will take a while to get so making a start. Wish me luck.
The question is how do you know if you truly suffer from depression? I have come off meds and get depression back but then back then I never spoke about my emotions or challenged my mindset. I am in a much more stable place now and think it is worth a go. There is depression in the family but then they have never spoken about their feelings either.
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