Effexor withdrawal

Posted by keola07 @keola07, Jul 1, 2023

Hello everyone, I have been in effexor for fifteen years been on 150 for seven. Finally found out a lot of my issues were do to ADHD so was on the wrong med. Finally think I found a good ADHD medsso been trying to lower my dose of effexor with psychatrist help. I went from 150 to 75. During the first few weeks felt vertigo and Shakey that went away. Then about four weeks into it felt body shocks. Now I feel like itchiness in scalp and tingling and brain zaps. Is this a normal side effects? Also thinking I jumped to big of a dose so thinking about going up 37.5 then taper off again from there. I do have a psych and he recommended that he is fantastic. It's been hard and stressful. But I am getting through it. Thank you for listening. Blessings.

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

Profile picture for mmsm @mmsm

I am in a similar place as you. I tapered from 225 to 75 over 4 weeks. I need to discontinue effexor because it caused my liver enzymes to get extremely high, and the doctor is concerned about my liver.
The first drop from 225 to 150 put me in the ER. Too much! My Dr. knew nothing about possible severe withdrawal symptoms. I sat there for two weeks. I decided the next reduction should be smaller, from 150 to 112.5. This was much better, with a few manageable side effects. That was one week. This week, I reduced from 112.5 to 75, and the anxiety has been awful. I'm exhausted, but can't sleep because my body and mind won't settle. I have burning nerve pain, tremors, and some nausea. Like you, my emotions are dysregulated, especially in the late afternoon.
I'm hoping my latest blood test shows some improvement in my liver enzymes, so I can at least feel like all the suffering has been for something.
I, too, would like to hear some success stories. I have a great support system, and talk to a therapist once a week. I'm lucky that I'm newly retired, so I can stay home to deal with this.
I hope things improve for all of us soon. It's all very scary because of all the unknowns.

Jump to this post

Thank you for your comment. I'm so sorry this is such a difficult trip for all of us. There has got to be a better way. I guess sharing info such as this will hopefully give info to the researchers to take into account when developing such meds and when trying to find ways to get off of them. Good luck with your journey. Praying for all who suffer from this. Glad you have some good support.

REPLY
Profile picture for smugzs @smugzs

I've been in a similar position as you, however I wasn't on Effexor nearly as long. It's a nasty beast to come off of at any rate, however. The only thing that helped me was when a doctor prescribed me a 30 day regimen of Prozac. After taking it for 3 days my symptoms subsided, and when the 30 days of Prozac was done I discontinued it with little to no side effects. I'm so sorry you're going through this, and I hope that you're able to find a solution.

Jump to this post

I am now down to 55 mg effexor (weighing the beads), and the horrible burning sensations are stronger than ever. It even feels like my heart is burning. My NP is looking into Prozac, hoping it will help with the withdrawal, both physically and emotionally.
Would you mind telling me more about your experience with prozac? Was it a cross taper, where you overlapped the two meds? Dosages? Did you have worse symptoms before they got better? Any details you can provide would really be appreciated.

REPLY
Profile picture for vicdenlee @vicdenlee

I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

Jump to this post

I’m so sorry for your struggles with discontinuing an SSRI. Hang in there as it will get better.
I am 70 years old and have been prescribed Paxil (40mg) for 15 years. My depression is serious and Honestly it was a life saver! Last summer my physician let me know that studies indicate this drug could cause - or worsen - dementia and it was time for me to stop. I began researching withdrawal side effects and was not happy as there were horror stories.
My MD wanted me to decrease by 10mg for 2 weeks then another 10…
I insisted that I would take it much more slowly starting with a 5mg reduction for several weeks.
I read one story where it took someone a year to completely discontinue an anti depressant so I felt encouraged by that.
My point is just that - don’t rush! I am down from 40mg to 15mg and feeling good. It might take 4 or 5 more months to complete and that’s okay.
Good luck and just know you are not alone.

REPLY
Profile picture for vicdenlee @vicdenlee

I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

Jump to this post

I was dropped from 75mg to 37.5 with a mood stabilizer. It wasn't intended as a tapering move, just a medical adjustment. I had made one near suicide attempt, and my psychiatrist was trying to adjust my drugs because she felt I was "flat" (her word). A few weeks later I went cold turkey in another suicidal fit (I do not recommend this, but in my case it proved to be a very good move). As I've mentioned in other threads, I subsequently learned that the drug itself was what was making me suicidal. A rare but documented phenomenon. After seeing how dramatically and rapidly I had changed, my psychiatrist agreed that I had been hit with this reaction. I went from daily thoughts of suicide for about three years to flat none for almost a full year now.

The primary side effects I experienced when I quit were vertigo, nausea, and the dreaded brain zaps. I found what helped the most was getting out every day and walking. I was doing about three miles. This really cleared my head and raised my energy level. The worst of the symptoms took about a month to lighten up. Then the emotional gushes set in about a month later. Those lasted well into the summer (I quit in February of last year). I had gone through a brief period when every member of my birth family except myself had died, however, and there was a lot of unresolved grief that I feel the drug had kept me from processing and that finally came out. So this was largely a good thing. Sometimes I could also be brought to tears by hearing about something good that had happened to someone. But for me this was evidence that I could feel things again.

Getting off of that drug was physically difficult, but by leaps and bounds the single best medical decision I ever made, even if I initially did it for all the wrong reasons.

REPLY
Profile picture for thatgirltrish @thatgirltrish

I’m so sorry for your struggles with discontinuing an SSRI. Hang in there as it will get better.
I am 70 years old and have been prescribed Paxil (40mg) for 15 years. My depression is serious and Honestly it was a life saver! Last summer my physician let me know that studies indicate this drug could cause - or worsen - dementia and it was time for me to stop. I began researching withdrawal side effects and was not happy as there were horror stories.
My MD wanted me to decrease by 10mg for 2 weeks then another 10…
I insisted that I would take it much more slowly starting with a 5mg reduction for several weeks.
I read one story where it took someone a year to completely discontinue an anti depressant so I felt encouraged by that.
My point is just that - don’t rush! I am down from 40mg to 15mg and feeling good. It might take 4 or 5 more months to complete and that’s okay.
Good luck and just know you are not alone.

Jump to this post

Thanks so much for your reply. I should have also mentioned that I really can't reduce my effexor slowly due to the fact that it has caused liver damage. I need to discontinue ASAP. I actually had a liver biopsy today to determine the extent of the damage. This is all so scary and I appreciate you saying it will get better. Sometimes, it sure doesn't feel like it!

REPLY
Profile picture for vicdenlee @vicdenlee

I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

Jump to this post

You are so brave! I've been on Effexor XR for twenty (or more?) years and at this point going off of it has not even become a discussion with my psychiatrist or therapist. If I forget to take it immediately after waking, I definitely notice within a few hours. Brain zaps, very strange yawning, feeling a bit faint.

REPLY
Profile picture for benegesserit @benegesserit

You are so brave! I've been on Effexor XR for twenty (or more?) years and at this point going off of it has not even become a discussion with my psychiatrist or therapist. If I forget to take it immediately after waking, I definitely notice within a few hours. Brain zaps, very strange yawning, feeling a bit faint.

Jump to this post

I am trying to taper off effexor, I am prescribed alprazolam.25mg as I take as needed, not often. Have you tried benzodiazepines to help Withdrawal?

REPLY
Profile picture for sliffer @sliffer

I am trying to taper off effexor, I am prescribed alprazolam.25mg as I take as needed, not often. Have you tried benzodiazepines to help Withdrawal?

Jump to this post

The doctors won't let me take anything right now, because nearly all meds are metabolized by the liver. I can't believe this is my life right now.

REPLY
Profile picture for mmsm @mmsm

The doctors won't let me take anything right now, because nearly all meds are metabolized by the liver. I can't believe this is my life right now.

Jump to this post

Oh no, I have not talked to my doctor yet, I had been really sick with RSV and kept forgetting to take my nighttime effexor. I also take tramadol for severe back pain that does help. I can't believe the doctor won't give you anything, my bff wanted off effexor and her doctor have her welbutrin. Prayers for you

REPLY
Profile picture for vicdenlee @vicdenlee

I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

Jump to this post

It’s sad but encouraging reading other people’s experiences with Effexor, I’ve been on 150mg twice daily for near ten years for depression and had no idea how huge that dose was. I’ve been dealing with Bruxism or grinding my teeth/clinching my jaw in my sleep and migraines for years as well and recently discovered theyre connected to high doses of Effexor. I’ve been hesitant to consider lowering the dosage because of the side effects of accidentally missing a day or two the bad headaches and shocks in my brain I get, but perhaps just a very prolonged decrease will do the trick

REPLY
Please sign in or register to post a reply.