Paxlovid Covid Rebound

That’s pretty rough getting a positive result twice in such a short time, I’m sorry for your troubles. I used Paxlovid when I was infected with Covid but the FDA only approved it for five days. I did get better after a short time but it all came back with a vengeance. I later read that a well known doctor had a rebound reaction. I don’t remember anyone saying that this would happen, I would have opted out. I basically had blamed it on the short term usage.

@frouke. Thanks so much. Also for your reply and input. I'm so sorry for your suffering also. I take full responsibility knowing my luck. Nurse told me she'd only seen a handful of cases. I'm thankful the others who were infected at same time and took it didn't have rebound or get long covid. I'm going on 11 months. Fortunately, I don't have a terrible case. But any stress just feeds it. Chronic Fatigue Syndrome and nausea are the worst. Hopefully, you are over it or getting better.?Thank you and good luck to you.

I was told it was a rare side effect but I think it was not rare at all, maybe even often. I got rebound too.

wendyaz47
Thanks for your reply and helpful input. So sorry to hear you got the double whammy too. I hope we got updated information at the time. Hope you didn't get Long Covid also.

I had Long Covid and got Pax for my second Covid infection. No effect, but likely because treatment was started several days after the recommended window. It took me 2 1/2 months to fully recover. With my 3rd Covid infection, I specifically asked for Pax with symptom onset. Doc did a video visit and phoned in a script which I started that same afternoon. Experienced symptom relief by the next day. Symptoms almost completely annihilated in the 5 days of treatment. Had a friend who got Covid at the same time as I (same dinner party). He took Pax and had a very similar experience. Footnote: Asked my PCP for Pax to address the Long Covid, but no go since it's not approved for LC. We keep on truckin'....

I was in ICU for 5 days severe case of covid. I now have long covid. My question is there anything I can take to kill off any spike protein left in my system?
I been out since Jan 1, 2005
Here what I was given in the ICU.
MEDS:Covid cocktail in ICU 5+ DAYS

1.Remdesivir: injection is used to treat coronavirus disease 2019 (COVID-19 infection) caused by the SARS-CoV-2 virus in hospitalized adults and children who weigh at least 3 pounds (1.5 kg). Remdesivir injection is also used to treat coronavirus disease 2019 (COVID-19 infection) caused by the SARS-CoV-2 virus in non-hospitalized adults and children 28 days and older who weigh at least 6.6 pounds (3 kg) who are at higRemdesivir injection is used to treat coronavirus disease 2019 (COVID-19 infection) caused by the SARS-CoV-2 virus in hospitalized adults and children who weigh at least 3 pounds (1.5 kg). Remdesivir injection is also used to treat coronavirus disease 2019 (COVID-19 infection) caused by the SARS-CoV-2 virus in non-hospitalized adults and children 28 days and older who weigh at least 6.6 pounds (3 kg) who are at high risk of progression to severe COVID-19, including hospitalization and death. Remdesivir is in a class of medications called antivirals. It works by stopping the virus from spreading in the body.

2.Lovenox: is used to treat or prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness.

3.Decadron/Dexamethasone:* is a highly potent and long-acting corticosteroid with high glucocorticoid activity and minimal mineralocorticoid activity. Dexamethasone is approximately six times more potent than prednisone. Used to treat arthritis, skin, blood, kidney, eye, thyroid, intestinal disorders, severe allergies, and asthma.
high risk of progression to severe COVID-19, including hospitalization and death. Remdesivir: is in a class of medications called antivirals. It works by stopping the virus from spreading in the body. Weight gain?

4.Lovenox is used to treat or prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness.
Thanks Scott

Thanks so much for all the info Scott. Very sorry for the long covid and all you've been through. Good thoughts and good luck going forward.

Corection on Date
so much for foggy memory!
I was in ICU for 5 days severe case of covid. I now have long covid. My question is there anything I can take to kill off any spike protein left in my system?
I BEEN OUT SINCE JAN 1, 2025.

Are you sure you weren’t just still positive with first case? I was positive 21 days.
I had rebound after Paxlovid, but I’m a nerdy retired nurse and wasn’t surprised. People can also have a worsening of Covid symptoms if they don’t get Paxlovid-the bad respiratory symptoms used to appear later.

I tested positive for 21 days and had low grade fevers longer, but symptoms weren’t severe and I had no respiratory difficulty. I reminded myself of that often because I was sick of it by 3 wks.

I’d take Paxlovid again in a heartbeat. I lived in Philadelphia near Penn Medicine at start of pandemic. Philly was hit early and hard, before vaccines and treatments were figured out. The hospital was inundated and deaths were frequent.

I do have Long Covid that I fear is permanent.