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Body making too much Vitamin B6

Chronic Pain | Last Active: Nov 25 8:40am | Replies (87)

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Sometimes the body accumulates too much B6 because of a condition called hypophosphatasia, which means your alkaline phosphatase enzyme levels are low due to a genetic mutation. After months from doctor to doctor that was my diagnosis. It's usually diagnosed with high B6, low alkaline phosphatase markers and a positive genetic test (heterozygous or homozygous recessive). Hope this helps!

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Replies to "Sometimes the body accumulates too much B6 because of a condition called hypophosphatasia, which means your..."

I came to the same result -high B6, alt was within range but on the low side, checked the genes and found heterozygous variant. Edited to say: I do not have hypo….? My genes don’t process enzymes as actively as they could. I also have the MTHFr variant and COMt. There is a lot of stress on the pathways. One has to take the active form of B6 P5P because the body may not actually be getting enough B6 if there is a bottleneck, pyroxidine is the inactive form. I still have undiagnosed problems though. Hashimotos (known) apparent swelling of lymph nodes, random unexplained pain. At one point I was diagnosed with fibromyalgia. I’ve had 15+ years trying to get to the bottom of it and labs come back normal so doctors just throw their hands up. I had to pay out of pocket to do additional testing to find TPO levels (thyroid antibodies) and nutrition. I have no science background so it’s been kind of interesting to learn all of this new information.