Hi I am taking hydrea 500 mg twice a day and once on alternative days...I have kak 2 and Calr bone marrow mutations..was on jakavi but take eliquis blood thinner for atrial fibrillation and was advised to.stop taking jakavi and go back on hydrea..I also inject with a medication to stimulate the bone marrow..the fatigue is unreal.any sort of activity like walking even short distance and I feel.weak and need to.sit .the fatigue is unreal.i am told I am.complicated any one else experience the fatigue